TERT-BUTYLDIMETHYLSILYL CYANIDE
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TERT-BUTYLDIMETHYLSILYL CYANIDE 속성
- 녹는점
- 76-79 °C (lit.)
- 끓는 점
- 163-165°C
- 밀도
- 0.815±0.06 g/cm3(Predicted)
- 인화점
- 45°C
- 용해도
- sol organic solvents (methylene chloride, THF, chloroform); reacts rapidly with water and protic solvents.
- Hydrolytic Sensitivity
- 8: reacts rapidly with moisture, water, protic solvents
- BRN
- 2234709
안전
위험품 표기 | T | ||
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위험 카페고리 넘버 | 23/24/25 | ||
안전지침서 | 36/37/39-45 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 1 | ||
WGK 독일 | 3 | ||
F 고인화성물질 | 10-21 | ||
TSCA | No | ||
위험 등급 | 6.1(b) | ||
포장분류 | III |
TERT-BUTYLDIMETHYLSILYL CYANIDE C화학적 특성, 용도, 생산
물리적 성질
bp 163–167°C/760 mmHg; mp 76–78°C.용도
The Lewis acid-catalyzed reaction of t-butyldimethylsilyl cyanide(TBDMSCN)with aldehydes and ketones affords the corresponding silylated cyanohydrins in good yield (eq 1).These have a greater stability than the silylated cyanohydrins obtained by using cyanotrimethylsilane The addition of TBDMSCN to sterically hindered ketones proceeds smoothly in the presence of a catalytic amount of zinc iodide or potassium cyanide/18-crown-6 (eqs 2–4).Achelation-controlled stereoselective synthesis of silylated cyanohydrins has also been reported (eq 5).제조 방법
conveniently prepared by refluxing t-butyldimethylchlorosilane (1 equiv), potassium cyanide (1.3 equiv) and 18-crown-6 (0.31 equiv) in dry methylene chloride under nitrogen.The reagent can also be prepared by the reaction of silver(I) cyanide with t-butyldimethylchlorosilane, or stirring at 60°C for 4 h a mixture of sodium cyanide, Amberlite XAD-4 resin, and t-butyldimethylchlorosilane in acetonitrile일반 설명
tert-Butyldimethylsilyl cyanide (TBDMSCN) is a bulkier trialkylsilylcyanide. It participates in the cyanosilylation of enantiopure 4-oxoazetidine-2-carbaldehydes. Addition of TBDMSCN to sterically hindered ketones in the presence of Lewis acid or base catalyst has been studied. ZnI2-catalyzed addition of TBDSCN to 2,2-dimethylcyclohexanone, 2,2,6-trimethylcyclohexanone and 2,2,6,6-tetramethylcyclohexanone affords protected cyanohydrins.TERT-BUTYLDIMETHYLSILYL CYANIDE 준비 용품 및 원자재
원자재
준비 용품
TERT-BUTYLDIMETHYLSILYL CYANIDE 공급 업체
글로벌( 33)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18627 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32835 | 60 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50003 | 58 |
Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 |
sales1@artkmedchem.com | China | 39010 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 |
sales@pharmablock.com | China | 4986 | 55 |
Meryer (Shanghai) Chemical Technology Co., Ltd. | 021-61259108 18621169109 |
market03@meryer.com | China | 40240 | 62 |
Energy Chemical | 021-021-58432009 400-005-6266 |
sales8178@energy-chemical.com | China | 44700 | 61 |