이보텐산
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이보텐산 속성
- 녹는점
- 141-147 °C
- 밀도
- 1.621±0.06 g/cm3 (20 ºC 760 Torr)
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- H2O: 가용성 1mg/mL, 투명, 무색(초음파 처리 포함)
- 물리적 상태
- 흰색 고체
- 산도 계수 (pKa)
- 2.16±0.10(Predicted)
- 색상
- 하얀색
- 냄새
- Practically odorless. Faint, meat-like, mild and sweet taste in aqueous dilutions.
- 수용성
- Soluble to 10 mM in water and to 100 mM in 1.1eq. NaOH
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. 증류수 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
- InChIKey
- IRJCBFDCFXCWGO-UHFFFAOYSA-N
- LogP
- -1.070 (est)
- CAS 데이터베이스
- 2552-55-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 23/24/25-25-40 | ||
| 안전지침서 | 45-38-36/37/39-28A-22-36 | ||
| 유엔번호(UN No.) | 1544 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | NY2100000 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| 독성 | LD50 in mice, rats (mg/kg): 15, 42 i.v.; 38, 129 orally (Theobald) | ||
| 기존화학 물질 | KE-05-0773 | ||
| 유해화학물질 필터링 | 97-1-224 | ||
| 함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 이보텐산 및 이를 1% 이상 함유한 혼합물 |
이보텐산 C화학적 특성, 용도, 생산
화학적 성질
Crystalline solid; forms monohydrate; mp151°C (303.8°F) (anhydrous), 145°C (293°F)(monohydrate); soluble in water and alcohol.용도
Ibotenic acid is a neuroexcitatory amino acid originally isolated from Amanita species that functions as a NMDA and metabotropic glutamate receptor agonist. As a neurotoxin, ibotenic acid is often used to induce brain lesions in animals that model cognitive dysfunctions resulting from neurodegenerative diseases, traumatic brain injury, and stroke.제조 방법
Isolated from the Japanese fly mushroom. The acid can be produced synthetically.정의
A isoxazole which, together with muscimol, is largely responsible for the toxicities of a number of mushrooms including those of the genus Amanita. It is a potent excitatory amino acid.위험도
Neurotoxic; causes motor depression, ataxia, changes in mood, perceptions and feelings.건강위험
Ibotenic acid is a potent neurologic aminoacid. It exhibits neuroexcitatory activity andcauses sedative actions on spinal neurons.High doses can cause sleep, hallucinations,distorted perceptions, and nausea. In humansthe symptoms above may be manifested fromingestion of 6–8 mg of ibotenic acid.LD50 value, oral (mice): 38 mg/kg
LD50 value, intraperitoneal (mice): 15 mg/kg.
생물학적 활성
NMDA and metabotropic glutamate receptor agonist.Purification Methods
It has been converted to the ammonium salt (m 121-123o dec) dissolved in H2O, passed through an Amberlite IR 120 resin (H+ form) and eluted with H2O. The acidic fractions are collected, evaporated to dryness and the residue recrystallises from H2O as the monohydrate (m 144-146o). The anhydrous acid is obtained by making a slurry with MeOH, decanting and evaporating to dryness, and repeating the process twice more to give the anhydrous acid (m 151-152o). Recrystallisation from H2O gives the monohydrate. [Nakamura Chem Pharm Bull Jpn 19 46 1971.] The ethyl ester forms needles when crystallised from a small volume of Et2O and has m 78-79o and IR (CHCl3) with max 35002300 (OH), 1742 (ester C=O), 1628, 1528cm-1, and UV with λmax (EtOH) at 206nm (ε 7,080). The hydrazide has m 174-175o (from MeOH) with IR (KBr) 1656 (C=O)cm-1.이보텐산 준비 용품 및 원자재
원자재
준비 용품
이보텐산 공급 업체
글로벌( 169)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ARCTIC EXPORTS INC | +1-3026880818 +1-3026880818 |
ARCTICEXPORTSINC@GMAIL.COM | Canada | 66 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20283 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32956 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29880 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 7724 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
이보텐산 관련 검색:
이보텐산
4-Phosphonophenylglycine
AIDA
L-AP4
L-AP3
(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
JNJ 16259685
(2R,4R)-APDC
MPPG
CPPG
IBOTENIC ACID MONOHYDRATE
L-Ibotenic acid
(R)-4-BROMO-HOMO-IBOTENIC ACID, >98%,(R)-4-BROMO-HOMO-IBOTENIC ACID
(S)-4-BROMO-HOMO-IBOTENIC ACID, >98%,(S)-4-BROMO-HOMO-IBOTENIC ACID
(RS)-4-BROMO-HOMO-IBOTENIC ACID
IBOTENIC ACID UN2811 (III)
IBOTENIC ACID(REAGENT / STANDARD GRADE)
TRICHOLOMIC ACID = DIHYDRO-IBOTENIC ACID