Myxothiazo;Myxothiazol;5-dimethoxy-4-methyl-;myxothiazolfrommyxobacterium;MYXOTHIAZOL, VIAL WITH 10 MG*;MYXOTHIAZOL FROM MYXOBACTERIUM 95%;MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS;myxothiazol from myxobacterium*myxococcus fulvus;7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide;2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-
6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications
Acute Tox. 2 Oral
그림문자(GHS):
신호 어:
Danger
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H300
삼키면 치명적임
급성 독성 물질 - 경구
구분 1,2
위험
P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
P264
취급 후에는 손을 철저히 씻으시오.
P264
취급 후에는 손을 철저히 씻으시오.
P270
이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P310
삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
믹소티아졸 C화학적 특성, 용도, 생산
용도
Myxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation.
정의
ChEBI: A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S
Biochem/physiol Actions
Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.
