D-과당-1,6-디인산염 트리나트륨 염

D-과당-1,6-디인산염 트리나트륨 염 C화학적 특성, 용도, 생산

용도

D-Fructose-1,6-bisphosphate trisodium salt is used to reduce ischemia-reperfusion injury in rats.

주요 응용

D-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It may be used as an allosteric activator of enzymes such as pyruvate kinase and NAD+-dependent L-(+)-lactate dehydrogenase, as an inhibitor of acetate kinase and as a substrate to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1,6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury.

Purification Methods

Fructose-1,6-diphosphate is best purified via the acid strychnine salt which is stable for several months. To remove the strychnine, dissolve 5g in H2O (150mL), and add 5N NaOH (or KOH to obtain the K salt) to pH 8.3 (phenolphthalein) with vigorous stirring. Remove the precipitate by centrifugation, wash with cold H2O (2x 25mL), extract with CHCl3 until the extract is free of strychnine (ca 8 to 10times, Mandelein spot test). Freeze-dry the aqueous solution to give the Na salt which is hygroscopic. It has been recrystallised from aqueous EtOH as the octahydrate, m 125o, [] D +2.6o (c 1, H2O). A neutral solution of the salt keeps well in a frozen state for over several months. [Neuberg et al. Arch Biochem 3 33 1943, Sable Biochemical Preparations 2 52 1952, Stumpf J Biol Chem 182 261 1950]. The calcium salt can be partially purified by dissolving in ice-cold N HCl (1g per 10mL) and re-precipitating by dropwise addition of 2N NaOH: the precipitate and supernatant are heated on a boiling water bath for a short time, then filtered, and the precipitate is washed with hot water. The magnesium salt can be precipitated from a cold aqueous solution by adding four volumes of EtOH. The tetramethyl ester is an oil with n D 1.4648, [] 18 +20.2 (c 0.4, MeOH). [Schulbach & Rauchenberger Chem Ber 60 1178 1927, Beilstein 1 IV 4424.]

D-과당-1,6-디인산염 트리나트륨 염 준비 용품 및 원자재

원자재

준비 용품

D-과당-1,6-디인산염 트리나트륨 염 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	lisa@kingfinertech.com	China	2989	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	4088	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	11820	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34571	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	info@fortunachem.com	China	5987	58

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