피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P308+P313
노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
NFPA 704
2
2
0
1-IODO-2-(TRIMETHYLSILYL)ACETYLENE 97 C화학적 특성, 용도, 생산
물리적 성질
bp 96 °C, 55 °C/20 mmHg; n20
D 1.5110;
d 1.46 g cm?3, fp 48°C.
용도
(Iodoethynyl)trimethylsilane is widely used as alkyne coupling reagent predominantly used in conjunction with
organocopper species or palladium catalysis.(Iodoethynyl)trimethylsilane has been largely
confined to aryl- and vinylcopper coupling, where it serves well
since the reverse procedure, i.e. coupling with alkynylcopper
reagents, is not straightforward due to the lack of reactivity of
alkynyl moieties bound to copper.
제조 방법
All involve iodination of trimethylsilylacetylenes.
Direct iodination of metalated (lithium or magnesium)
trimethylsilylacetylene has been largely supplanted
due to the modest yields obtained. Utilizing trimethylsilylacetylene
and bis(trimethylsilyl) peroxide in the presence
of copper(I) iodide gives good yields. Substituting zinc
iodide requires using the lithium acetylide. Copper(I) iodide
(0.05 equiv.) in the presence of iodine, sodium carbonate, and
a phase-transfer catalyst gives good yields without having to
use n-butyllithium or a Grignard reagent to first deprotonate
the trimethylsilylacetylene. The most popular procedure uses
bis(trimethylsilyl)acetylene, treating it with iodine monochloride
in dichloromethane at 25°Cto obtain excellent yields of
(iodoethynyl)trimethylsilane.