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NFPA 704
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4
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NIDA-41020 C화학적 특성, 용도, 생산
용도
NIDA 41020 is an analog of rimonabant, which is a CB1 cannabinoic receptor antagonist that diminishes the behavioral effects of opiates and nicotine.
Biochem/physiol Actions
NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB1 receptors, Ki = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have Ki of 0.6, 4.5 and 1.8 nM respectively].