ChemicalBook >제품 카탈로그 >생화학 공학>억제제>PI3K / Akt / mTOR>PI3K 억제제>ZSTK474

ZSTK474

ZSTK474 구조식 이미지

카스 번호:: 475110-96-4

상품명:: ZSTK474

동의어(영문):: CS-438;ZSTK 474;ZSTK474 BASE;ZSTK474/ZSTK-474;ZSTK474 USP/EP/BP;2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine;2-(DifluoroMethyl)-1-[4,6-di(4-Morpholinyl)-1,3,5-triazin-2-yl]-1H-benziMidaz;1-[BIS(MORPHOLIN-4-YL)-1,3,5-TRIAZIN-2-YL]-2-(DIFLUOROMETHYL)-1,3-BENZODIAZOLE;2-(difluoromethyl)-1-(4,6-dimorpholino-1,3,5-triazin-2-yl)-1H-benzo[d]imidazole;ZSTK 474 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine

CBNumber:: CB0505419

분자식:: C19H21F2N7O2

포뮬러 무게:: 417.41

MOL 파일:: 475110-96-4.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 156

ZSTK474 속성

녹는점: 217-219 °C(Solv: ethanol (64-17-5))

끓는 점: 640.3±65.0 °C(Predicted)

밀도: 1.57

저장 조건: -20°C

용해도: DMSO(최대 20mg/ml) 또는 에탄올(가온 시 최대 2.5mg/ml)에 용해됩니다.

물리적 상태: 백색 분말.

산도 계수 (pKa): 5.21±0.10(Predicted)

색상: 흰색 또는 황백색

안정성: 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.

안전

HS 번호	29349990

ZSTK474 C화학적 특성, 용도, 생산

용도

ZSTK474 is a triazine derivative that acts as an inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms (IC50s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively). It is selective for PI3K, as it has negligible activity against 139 other kinases when tested at 30 μM. ZSTK474 is orally bioavailable and shows strong antitumor activity against human cancer xenografts in mice. The efficacy of ZSTK474 against certain cancer cells and tumors can be enhanced by combination therapy.

정의

ChEBI: A triamino-1,3,5-triazine that is 1,3,5-triazine in which two of the hydrogens have been replaced by morpholin-4-yl groups while the third hydrogen has been replaced by a 2-(difluoromethyl)benzimidazol-1-yl group. It is an inhibitor of phosphatidylinositol 3-kinase.

ZSTK474 준비 용품 및 원자재

원자재

준비 용품

ZSTK474 공급 업체

글로벌( 156)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22883	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58

ZSTK474 관련 검색:

Z-VAD-FMK ZM 336372 (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Troglitazone Z-PRO-OSU Z-SAR-OH Z-PHE-ALA-DIAZOMETHYLKETONE Z-PHE-NH2 Z-PHE-ALA-OH Z-PHE-PNA Z-PHE-ONP Z-PHE-OSU Imatinib mesylate PD 0325901 CAL-101 Ibrutinib LY 294002 HYDROCHLORIDE BEZ235 (NVP-BEZ235, Dactolisib)