5-메톡시트립타민
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5-메톡시트립타민 속성
- 녹는점
- 121-123 °C (lit.)
- 끓는 점
- 325.75°C (rough estimate)
- 밀도
- 1.0815 (rough estimate)
- 굴절률
- 1.5700 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 수정 같은
- 산도 계수 (pKa)
- 16.91±0.30(Predicted)
- 색상
- 하얀색
- Merck
- 13,6032
- BRN
- 145587
- InChI
- InChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3
- InChIKey
- JTEJPPKMYBDEMY-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(OC)C=C2)C(CCN)=C1
- CAS 데이터베이스
- 608-07-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-20/21/22 | ||
안전지침서 | 36-26 | ||
WGK 독일 | 3 | ||
RTECS 번호 | NL4110000 | ||
F 고인화성물질 | 8 | ||
HS 번호 | 29339900 | ||
독성 | LD50 intraperitoneal in mouse: 176mg/kg |
5-메톡시트립타민 C화학적 특성, 용도, 생산
개요
5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels.It is biosynthesized via the deacetylation of melatonin in the pineal gland.The protective effect of 5-methoxytryptamine (a metabolite of melatonin) in human keratinocytes against ultraviolet B (UVB) radiation was studied.
Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes.
화학적 성질
White to tan crystalline powder용도
5-Methoxytryptamine (Mexamine, Methoxytryptamine) is a tryptamine derivative that is closely related to the neurotransmitter Melatonin (M215000) and Serotonin (S274980). It acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors but has no affinity for the 5-HT3 receptor.주요 응용
5-Methoxytryptamine was used as an agonist in the study of pharmacological profile of the 5-hydroxytryptamine 1 receptor.Reactant for preparation of:
Carboline disaccharide domain of shishijimicin A
Melatonin analogs for the reduction of intraocular pressure
5-HT4 receptor ligands
inhibitors of sortase A and isocitrate lyase
Therapeutic agents for treatment of ischemia/reperfusion (I/R) injury
Aurora and epidermal growth factor receptor kinase inhibitors
Agents for the treatment of human papillomavirus infection
Manzamine analogues for the control of neuroinflammation and cerebral infections
Inhibitors of pro-inflammatory cytokines
Tacrine-melatonin hybrids as multifunctional agents for alzheimer′s disease
정의
ChEBI: 5-methoxytryptamine is a member of the class of tryptamines that is the methyl ether derivative of serotonin. It has a role as a serotonergic agonist, a human metabolite, a mouse metabolite, a 5-hydroxytryptamine 2A receptor agonist, a 5-hydroxytryptamine 2C receptor agonist, a 5-hydroxytryptamine 2B receptor agonist, an antioxidant, a radiation protective agent, a neuroprotective agent and a cardioprotective agent. It is a member of tryptamines, an aromatic ether and a primary amino compound. It derives from a serotonin. It is a conjugate base of a 5-methoxytryptamine(1+).일반 설명
The protective effect of 5-methoxytryptamine (a metabolite of melatonin) in human keratinocytes against ultraviolet B (UVB) radiation was studied.5-메톡시트립타민 준비 용품 및 원자재
원자재
준비 용품
5-메톡시트립타민 공급 업체
글로벌( 491)공급 업체
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5-메톡시트립타민 관련 검색:
P-아니시딘 트리플르오르메톡시벤젠 아니졸 아니스알데히드 메톡시벤질클로라이드 메틸 술폰
4-Methoxyphenylacetone
Serotonin hydrochloride
3-(METHOXYMETHOXY)BENZALDEHYDE
Melatonine
Methoxyammonium chloride
5-Methoxytryptamine hydrochloride
2-PHENYLMELATONIN
N-Acetyl-2-iodo-5-methoxytryptamine
6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE
2-(5-BENZYLOXY-1H-INDOL-3-YL)-ETHYLAMINE
IBOGAINE HYDROCHLORIDE--DEA*SCHEDULE I I TEM
6-METHOXYTRYPTAMINE