Iloprost

Iloprost 구조식 이미지
카스 번호:
73873-87-7
상품명:
Iloprost
동의어(영문):
Ilopros;ILOPROST;CILOPROST;Iloprost USP/EP/BP;Iloprost (for research only);6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-16-METHYL-PROSTA-5E,13E-DIEN-18-YN-1-OIC ACID
CBNumber:
CB0775438
분자식:
C22H32O4
포뮬러 무게:
360.49
MOL 파일:
73873-87-7.mol

Iloprost 속성

저장 조건
Amber Vial, -20°C Freezer, Under inert atmosphere
용해도
클로로포름(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
고체
물리적 상태
단단한 모양
색상
무색~담황색
안정성
감광성

안전

Iloprost C화학적 특성, 용도, 생산

용도

Treatment of pulmonary hypertension (prostacyclin analogue).

일반 설명

This more chemically and biologically stable derivativeof prostacyclin is available as a solution (10 μg/mL)for nasal inhalation (Ventavis by Actelion) via a preciselycalibrated inhalation device for the treatment of pulmonaryarterial hypertension (PAH). Patients inhale 6 to 8 puffs ofaerosolized iloprost every 2 to 3 hours to produce a directvasodilatory effect on pulmonary blood vessels, therebydecreasing vascular resistance. Side effects of coughing,flushing, headaches, and jaw pain have been most commonlyreported.

Clinical Use

Iloprost is administered as an inhalation solution of a prostacyclin analog for the treatment of NYHA class III and class IV PAH. The drug also can be administered as an IV infusion. It is stable at room temperature and to light, with a body half-life of 30 minutes. Iloprost has approximately 10 times greater potency than prostacyclin as a vasodilator of the pulmonary blood vessels; this greater potency of inhaled iloprost results from coating of the drug on the alveoli of the lungs.

부작용

Studies have reported minor side effects, such as coughing, headaches, and jaw pain.

Iloprost 준비 용품 및 원자재

원자재

준비 용품


Iloprost 공급 업체

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Alfa Chemistry

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