피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
3
3
0
N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE C화학적 특성, 용도, 생산
화학적 성질
Clear colorless liquid
물리적 성질
bp 137–139°C, 78–80°C/100 mmHg; d 0.830
g cm?3; flash point 28°C.
용도
N,O-Bis(trimethylsilyl)hydroxylamine
is a protected, lipophilic form of hydroxylamine. It reacts
with a variety of electrophiles predominantly by attack on the nitrogen
nucleophilic center. Reaction with acid chlorides (1 equiv)
in the presence of triethylamine gives N,O-bis(trimethylsilyl)-
hydroxamic acids by N-acylation.A related reagent, tris(trimethylsilyl)
hydroxylamine, gives the same product in high yields,
also by N-acylation.Hydrolysis gives the free hydroxamic
acids, whereas thermal fragmentation affords isocyanates (eq 1).
제조 방법
N,O-Bis(trimethylsilyl)hydroxylamine can be prepared in 69% yield by treating
dry hydroxylamine with equiv chlorotrimethylsilane and
equiv triethylamine.A safer preparation, which avoids the
use of the explosive solid, hydroxylamine, uses the reaction
of hydroxylamine hydrochloride with excess hexamethyldisilazane
(71–75% yield).Alternatively, neutralization of hydroxylamine
hydrochloride with ethylenediamine followed by
addition of chlorotrimethylsilane can be used.
일반 설명
N,O-Bis(trimethylsilyl)hydroxylamine on reaction with 9-chloro-9-borafluorene yields 10-trimethylsilyloxy-9-aza-10-boraphenanthrene. It reacts with free phenolic steroids during the analysis of conjugated estrogen tablets and injectable formulations by GLC.