곰팡이크로민

곰팡이크로민
곰팡이크로민 구조식 이미지
카스 번호:
6834-98-6
한글명:
곰팡이크로민
동의어(한글):
곰팡이크로민
상품명:
Fungichromin
동의어(영문):
Lagosin;Cogomycin;Fungichromin;Lagosin【antibiotic】;(3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one;Oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-, (3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-
CBNumber:
CB0904201
분자식:
C35H58O12
포뮬러 무게:
670.83
MOL 파일:
6834-98-6.mol

곰팡이크로민 속성

녹는점
157-162° (dec)
알파
D20 -227.7° (c = 0.53 in DMF)
끓는 점
914.0±65.0 °C(Predicted)
밀도
1.196±0.06 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
DMSO에 용해됨
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
12.77±0.70(Predicted)
색상
Light yellow to yellow

안전

독성 LD50 in mice (mg/kg): 1624 orally; 33.3 i.p. (Umezawa, Tanaka)

곰팡이크로민 C화학적 특성, 용도, 생산

용도

Lagosin is a pentaene antifungal produced by Streptomyces, first isolated in 1958 by researchers at MIT in the USA. The discovery was soon followed by several independent isolations as lagosin and cogomyin. Initially these metabolites were thought to be isomeric, but Pandey and colleagues at NCI definitively demonstrated they were identical. Structurally, lagosin is 14-hydroxyfilipin III and the most polar member of the filipin family of fungicides. Lagosin exhibits broad spectrum antifungal and antitumor activity and, like filipin, acts via interaction with cell membrane sterols.

곰팡이크로민 준비 용품 및 원자재

원자재

준비 용품


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