Before aging occurs, patients can be treated with pralidoxime, which breaks the
phosphorus–enzyme complex and regenerates the enzyme. Pralidoxime is a strong nucleophile. It reactivates phosphorylated enzymes in a two-staged reaction. First, a complex is
formed between the oximate ion and the phosphorylated enzyme. Second, enzyme activity is restored and phosphorylated oxime is formed. The high reactivating ability of pralidoxime is attributed to its ability to combine with a negatively charged group on the
surface of an enzyme and a high level of molecular correlation between oxime and phosphorylated cholinesterase. It is possible that oximes may react directly with the inhibitor,
turning it into a harmless compound as well as reactivating the inhibitory enzyme both in
blood and in tissue.
용도
Pralidoxime is used for treating organophosphate poisonings, paralysis of skeletal muscle, and in general for cholinesterase crisis.
정의
ChEBI: A pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2.
![2-[(히드록시이미노)메틸]-1-메틸피리디늄](CAS/GIF/6735-59-7.gif)