2-티오펜아세트산,알파-히드록시-알파-2-티에닐-,(1R,3R,5R)-6,6-트리메틸-9-아자비시클로(9)논-3.3.1-일에스테르,염산염,rel- C화학적 특성, 용도, 생산
Originator
Pentona, Tanabe ,Japan ,1978
Manufacturing Process
A mixture of 1.0 g of 6,6,9-trimethyl-9-azabicyclo[3.3.1]nonan-3β-ol, methyl α,α-di-(2-thienyl)-glycolate and 30 mg of metallic sodium is heated at 80°C to 90°C for about 2 hours under reduced pressure. After cooling, ether is added to the reaction mixture. The mixture is extracted with 10% hydrochloric acid. The aqueous layer is alkalified with sodium carbonate and reextracted with ethyl acetate. The extract is washed with water, dried and concentrated to dryness. The residue thus obtained is treated with hydrogen chloride by conventional manner. 2.0 g of the α,α-di-(2-thienyl)glycolate of 6,6,9- trimethyl-9-azabicyclo[3.3.1]nonan-3β-ol hydrochloride are obtained. Yield 83%.
Therapeutic Function
Antiparkinsonian
2-티오펜아세트산,알파-히드록시-알파-2-티에닐-,(1R,3R,5R)-6,6-트리메틸-9-아자비시클로(9)논-3.3.1-일에스테르,염산염,rel- 준비 용품 및 원자재
원자재
준비 용품
2-티오펜아세트산,알파-히드록시-알파-2-티에닐-,(1R,3R,5R)-6,6-트리메틸-9-아자비시클로(9)논-3.3.1-일에스테르,염산염,rel- 공급 업체
