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Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate

Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate 구조식 이미지

카스 번호:: 138923-03-2

상품명:: Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate

동의어(영문):: (1S,4R)-Methyl 4-aMinocyclopent-2-enecarboxylate;methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate;Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate;(1S,4R)-2-CYCLOPENTENE-1-CARBOXYLIC ACID, 4-AMINOMETHYL ESTER;(1S,4R)-Methyl 4-aMinocyclopent-2-enecarboxylate L-tartrate salt;Cis-(1S,4R)-4-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester;2-Cyclopentene-1-carboxylic acid, 4-amino-, methyl ester, (1S,4R)-;2-Cyclopentene-1-carboxylicacid,4-amino-,methylester,(1S,4R)-(9CI)

CBNumber:: CB11286228

분자식:: C7H11NO2

포뮬러 무게:: 141.17

MOL 파일:: 138923-03-2.mol

속성

안전

용도

공급 업체 26

Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate 속성

끓는 점: 191.9±40.0 °C(Predicted)

밀도: 1.109±0.06 g/cm3(Predicted)

저장 조건: 2-8°C

산도 계수 (pKa): 9.66±0.40(Predicted)

안전

Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate C화학적 특성, 용도, 생산

용도

Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Weigh 50g of the by-product (+)1-amino-4-carboxy-2-cyclopentene extracted by γ-lactam enzymatic resolution and put it in a flask, add 200g of water, and slowly add dropwise at 25~30℃ Sulfuric acid, adjust the pH value of the solution to 1~2, after the dripping is completed, add 0.1g of the racemic catalyst o-phthalaldehyde, then heat to reflux, and react for 10~15h. Concentrate under reduced pressure to no fraction, add 200ml of methanol, 20g of tartaric acid, cool to 10-20°C, filter and wash with methanol. Then add 20g of thionyl chloride and 100ml of methanol to the filter cake, react at 65°C for 8h and concentrate under reduced pressure until there is no fraction. Add 100ml of dichloromethane, stir to dissolve and wash the dichloromethane layer twice with drinking water to obtain (- ) Methyl 1-amino-4-carboxylate-2-cyclopentene in dichloromethane solution, yield 42%.

Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate 준비 용품 및 원자재

원자재

(+)-주석산암모늄

준비 용품

Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate 공급 업체

글로벌( 26)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32951	60
NINGBOBENKANGJS PHARMTECHCO., LTD	+8615990591583 15990591583		CHINA	2029	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	7514	58
R&D Scientific Inc.	+1-2266000236	sales@rdscientific.com	Canada	1576	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd.	15990591583		China	5573	58
Acesys Pharmatech	18860950986	tangmanman@zenjipharma.com	China	1733	55
Shanghai Kewel Chemical Co., Ltd.	021-64609169 18901607656	greensnown@163.com	China	9906	50
Wuxi Biortus Biosciences Co. Ltd.	+86-510-86130723	lfeng@biortus.com	China	174	55