L-트레오-디하이드로스핑고신
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L-트레오-디하이드로스핑고신 속성
- 녹는점
- 126-128 °C
- 끓는 점
- 446.2±25.0 °C(Predicted)
- 밀도
- 0.927±0.06 g/cm3(Predicted)
- 인화점
- 110 °C
- 저장 조건
- -20°C
- 용해도
- ≤0.25mg/ml in ethanol
- 물리적 상태
- 흰색 고체
- 산도 계수 (pKa)
- 12.57±0.45(Predicted)
안전
WGK 독일 | 3 |
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L-트레오-디하이드로스핑고신 C화학적 특성, 용도, 생산
용도
L-threo-Dihydrosphingosine is a lyso-sphingolipid protein kinase C inhibitor. It suppresses the growth of human oral squamous cell carcinoma (SCC) cells.일반 설명
A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Inhibits enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC (IC50 = 37.5 μM and 31 μM, respectively). Inhibits human PKCα, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 μM). Enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC; Cat. Nos. 47589 and 475820) in gastric cancer cells by promoting drug-induced apoptosis.Biochem/physiol Actions
Sphingosine kinase inhibitor; protein kinase C alpha (PKCα) -specific inhibitor; Sphingosine analog; potentiates the effect of doxorubicin (DOX) in tumor-bearing animals.L-트레오-디하이드로스핑고신 준비 용품 및 원자재
원자재
준비 용품
L-트레오-디하이드로스핑고신 공급 업체
글로벌( 66)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30250 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50003 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 94658 | 76 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 |
isunpharm@qq.com | China | 4428 | 55 |
Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 |
root@zhongyitai.com | China | 1977 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
Alfa Chemistry | 1-516-6625404 |
support@alfa-chemistry.com | United States | 9171 | 60 |
Codow Chemical Co.,Ltd. | 18620099427 |
amy@howeipharm.com | China | 17698 | 55 |
L-트레오-디하이드로스핑고신 관련 검색:
D-THREO-DIHYDROSPHINGOSINE
DL-THREO-DIHYDROSPHINGOSINE
N-DODECANOYL-NBD-L-THREO-DIHYDROSPHINGOSINE,N-C12-NBD-L-THREO-DIHYDROSPHINGOSINE, FLUORESCENT
C6 NBD-L-THREO-DIHYDROSPHINGOSINE
DIHYDROSPHINGOSINE, L-THREO [4,5-3H]
C12 NBD-L-THREO-DIHYDROSPHINGOSINE
N-C6-NBD-L-THREO-DIHYDROSPHINGOSINE, FLUORESCENT,N-HEXANOYL-NBD-L-THREO-DIHYDROSPHINGOSINE
Cedefingol
L-THREO-DIHYDROSPHINGOSINE