N-메틸코나닌-5-en-3β-아민 C화학적 특성, 용도, 생산
개요
A pregnene type alkaloid found in the bark and seeds of Holarrhena antidysenterica Wall., the base yields a hydrate, m.p. 88-92°C and has [α]
25D + 30.0°
(aqueous EtOH). It is freely soluble in most organic solvents. It yields a series of
crystalline salts and derivatives, e.g. the hydrochloride, m.p. 334-335°C (dec.);
hydrobromide, m.p. 344°C; hydriodide, m.p. 316°C; platinichloride, m.p. 285°C (dec.); methiodide, m.p. 290°C (dec.) and the picrate, m.p. 198-200°C. The
N-acetyl derivative has also been prepared, m.p. 161°C yielding a hydrochloride,
m.p. 325-6°C, as has the benzoyl compound, m.p. l59-l60°C, also forming a
hydrochloride, m.p. 325-6°C (dec.).
On methylation, the alkaloid yields conessine and heating with dilute H2S04
isomerizes the base to isonorisoconessine, [0:]5S + 101 ° (EtOH), furnishing a
hydriodide, m.p. 289°C (dec.) and a picrate, m.p. 166°C.
참고 문헌
Siddiqui.,J. Ind. Chern. Soc., 11,283 (1934)
Siddiqui, Siddiqui., ibid, 11,787 (1934)
Haworth, McKenna, Whitfield.,J. Chern. Soc., 1102 (1953)
N-메틸코나닌-5-en-3β-아민 준비 용품 및 원자재
원자재
준비 용품
