조니포라이드이염화물

조니포라이드이염화물
조니포라이드이염화물 구조식 이미지
카스 번호:
241800-97-5
한글명:
조니포라이드이염화물
동의어(한글):
조니포라이드이염화물
상품명:
ZONIPORIDE DIHYDROCHLORIDE
동의어(영문):
Zoniporide dihydroch;ZONIPORIDE DIHYDROCHLORIDE;[1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine hydrochloride;[1-(QUINOLIN-5-YL)-5-CYCLOPROPYL-1H-PYRAZOLE-4-CARBONYL]GUANIDINE DIHYDROCHLORIDE;5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide:hydrochloride
CBNumber:
CB12453438
분자식:
C17H17ClN6O
포뮬러 무게:
356.81
MOL 파일:
241800-97-5.mol

조니포라이드이염화물 속성

저장 조건
Desiccate at -20°C
용해도
≤1mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
물리적 상태
결정질 고체
안정성
흡습성

안전

조니포라이드이염화물 C화학적 특성, 용도, 생산

용도

The sodium-hydrogen exchanger isoform-1 (NHE-1) is the most predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis. It plays an important role in the myocardial response to ischemia-reperfusion. Zoniporide inhibits human NHE-1 with an IC50 value of 14 nM, displaying greater than 150-fold selectivity over other NHE isoforms. It has been shown to reduce infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function. In isolated heart, zoniporide reduced infarct size with an EC50 value of 0.25 nM.

조니포라이드이염화물 준비 용품 및 원자재

원자재

준비 용품


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