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N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride 구조식 이미지

카스 번호:: 313553-47-8

상품명:: N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride

동의어(영문):: INH1;CS-1011;IBT 13131;INH1 (IBT13131);INH1, 10 mM in DMSO;Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1;N-(4-(2,4-Dimethylphenyl)thiazol-2-yl)benzamide;N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-benzamide;Benzamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-;N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride

CBNumber:: CB12518874

분자식:: C18H16N2OS

포뮬러 무게:: 308.4

MOL 파일:: 313553-47-8.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 110

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride 속성

밀도: 1.239±0.06 g/cm3 (20 ºC 760 Torr)

저장 조건: Sealed in dry,2-8°C

용해도: ≥30.8 mg/mL in DMSO; insoluble in H2O; ≥12 mg/mL in EtOH

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: White to off-white

CAS 데이터베이스: 313553-47-8

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride C화학적 특성, 용도, 생산

일반 설명

A cell-permeable thiazolyl benzamide compound that directly binds Hec1 and disrupts Hec1/Nek2 complex formation, resulting in defective Hec1 kinetochores localization and cellular Nek2 destabilization/downregulation. Shown to induce a transient mitotic arrest in HeLa cultures and inhibit the proliferation of 10 breast cancer cell lines (GI₅₀ of 10-21 μM) as well as the cervical HeLa and colon HCT116 cancer lines, while exhibiting reduced potency against the noncancerous MCF10A line (GI₅₀ = 41 μM). Reported to suppress the MDA-MB-468-derived tumor growth (by ~53% and ~75% 3 wks after a 7-wk treatment period with 50 mg/kg and 100 mg/kg INH1, repectively, i.p.) in a murine breast cancer model in vivo.

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride 준비 용품 및 원자재

원자재

준비 용품

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride 공급 업체

글로벌( 110)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32965	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22787	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Golden Pharma Co., Limited	+undefined18958062155	sales@zjgoldpharm.com	China	5899	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride 관련 검색:

N-Methylaniline N,N-DIMETHYLHYDROXYLAMINE HYDROCHLORIDE N,N'-Dimethyl-1,3-propanediamine N,N-Dimethylbenzylamine N,N-Dimethylbenzamide N,N-Dimethylpropionamide YM155 (Sepantronium Bromide) Combretastatin A4 phosphate disodium salt NMS-P937 (NMS1286937) 3-Chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide Docetaxel MLN8054