A419259삼염산염
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A419259삼염산염 속성
- 끓는 점
- 686.4±55.0 °C(Predicted)
- 밀도
- 1.29±0.1 g/cm3(Predicted)
- 저장 조건
- room temp
- 용해도
- H2O: 가용성10mg/mL(투명 용액)
- 산도 계수 (pKa)
- 8.20±0.42(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
안전
WGK 독일 | 3 |
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A419259삼염산염 C화학적 특성, 용도, 생산
개요
A-419259 is an inhibitor of Src family kinases, including Src, LCK, Lyn, and Hck (IC50s = 9, <3, <3, and 11.26 nM, respectively)., It is selective for these kinases over c-Abl (IC50 = 3,000 nM) and PKC (IC50 = >33 μM). A-419259 inhibits growth of Philadelphia chromosome-positive (Ph+) K-562 and Meg-01 myeloid leukemia cells (IC50s = 0.1-0.3 and 0.1 μM, respectively), but not Ph- TF-1 and HEL cells. It induces apoptosis in K-562 cells in a concentration-dependent manner. A-419259 (300 nM) inhibits differentiation of murine embryonic stem cells while maintaining pluripotency. It reduces the total number of acute myeloid leukemia (AML) cells, as well as AML stem cells, in the bone marrow and spleen in mouse patient-derived xenograft (PDX) models of AML when administered at a dose of 30 mg/kg twice daily.A419259삼염산염 준비 용품 및 원자재
원자재
준비 용품
A419259삼염산염 공급 업체
글로벌( 33)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30250 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
MedChemexpress LLC | 021-58955995 |
sales@medchemexpress.cn | United States | 4863 | 58 |
AdooQ BioScience, LLC | +1 (866) 930-6790 |
info@adooq.com | United States | 2784 | 58 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 |
sales-cpd@caerulumpharma.com | China | 3466 | 58 |
LETOPHARM LIMITED | +86-21-5821 5861 |
sales@letopharm.com | China | 2384 | 58 |
SPIRO PHARMA | |
eric_feng1954@126.com | China | 9254 | 55 |
Musechem | +1-800-259-7612 |
info@musechem.com | United States | 4662 | 60 |
Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 |
sale1@shzysw.net | China | 9772 | 58 |