Debio-1347
|
|
Debio-1347 속성
- 끓는 점
- 775.5±55.0 °C(Predicted)
- 밀도
- 1.51±0.1 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- ≥35.6 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 10.51±0.10(Predicted)
- 색상
- Off-white to yellow
- CAS 데이터베이스
- 1265229-25-1
안전
Debio-1347 C화학적 특성, 용도, 생산
용도
CH5183284 is an orally available and selective FGFR (fibroblast growth factor receptor) inhibitor acting on FGFR 1, 2, and 3.Synthesis
The synthesis of Debio-1347 is as follows:An aqueous solution (1.67 ml) of 4 M sodium hydroxide was added to an ethanol solution (17 ml) of [5-amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl]-(1-benzenesulfonyl-1H-indol-2-yl) methanone (87 mg). The resulting mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into water. The resulting solid was collected by filtration, washed with water, and dried to give Debio-1347 (40 mg, 63%).
Debio-1347 준비 용품 및 원자재
원자재
1-(phenylsulfonyl)-1H-indole-2-carboxylic acid ethyl ester
1H-Indole-2-propanenitrile, β-oxo-1-(phenylsulfonyl)-
3-(Dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile
준비 용품
Debio-1347 공급 업체
글로벌( 113)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32956 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29810 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32161 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 |
info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10473 | 58 |
| CR Corporation Limited | +8613062833949 |
fred.wen@crcorporation.cn | China | 8647 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38631 | 58 |
| Shanghai Huici Pharmaceutical Technology Co., LTD | +8618917134367 |
lixing@pharmahuici.com | China | 133 | 58 |