GAMBOGIC ACID
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GAMBOGIC ACID 속성
- 녹는점
- 88.5°C
- 끓는 점
- 586.06°C (rough estimate)
- 알파
- D20 -685° (methanol)
- 밀도
- 1.1057 (rough estimate)
- 굴절률
- 1.5290 (estimate)
- 저장 조건
- -20°C
- 용해도
- DMSO: ≥10mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 4.58±0.36(Predicted)
- 색상
- 노란색에서 주황색으로
- 안정성
- 공급된 대로 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
- InChIKey
- GEZHEQNLKAOMCA-XKZIYDEJSA-N
- LogP
- 6.490 (est)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T | ||
---|---|---|---|
위험 카페고리 넘버 | 25-36/37/38 | ||
안전지침서 | 26-45 | ||
유엔번호(UN No.) | UN 2811 6.1 / PGIII | ||
WGK 독일 | 1 | ||
RTECS 번호 | PB9268200 | ||
HS 번호 | 29189900 | ||
독성 | LD50 unreported in mammal (species unspecified): 55mg/kg |
GAMBOGIC ACID C화학적 특성, 용도, 생산
용도
antiinflammatory, cytotoxic, inhibits HeLa cells in vitro;정의
ChEBI: A natural product found in Garcinia hanburyi.일반 설명
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG생물학적 활성
Natural product isolated from the Garcinia hanburyi tree. Induces apoptosis in several tumor cell lines including T47D cells. Activates caspases with an EC 50 value of 0.78-1.64 μ M and competitively inhibits antiapoptotic Bcl-2 family proteins (IC 50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μ M for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Also blocks K IR 2.1 channels (EC 50 ≤ 100 nM).Anticancer Research
Gambogic acid is a xanthonoid, also known as kokum that is a resin from Garciniaindica, that can inhibit the proliferation of human breast, hepatoma, lung, and gastriccarcinoma cells. It is also an apoptotic inducer and inhibits telomerase and theexpression of telomerase reverse transcriptase mRNA and its promoter. It also suppressesCDK7-mediated CDC2/p34 phosphorylation, downregulates Bcl-2, andinteracts with c-myc. By interacting with transferrin receptors, it mediates apoptosisof cancer cells. It inhibits NF-κB pathway. In vivo and in vitro experiments determinedits potential to inhibit angiogenesis and VGEF-2 receptor, and thus it inhibitshuman endothelial cell growth, invasion, and migration, microvessel growth, andtube formation (Zhang et al. 2004; Pandey et al. 2007; Aggarwal et al. 2008).GA, extract from Garcinia hanburyi, the most important active constituent of gamboge,inhibits the heat shock protein (Hsp90) (Zhang 2010). Hsp90 is the majorprotein in tumour regeneration as well as cell signalling, and its inhibition results ininduction of ER stress, thereby activating UPR target genes and ER stress sensorswhich further cause cell death (Lamoureux et al. 2014). Severe or sustained ERstress increases CHOP expression and stimulates IRE1α apoptotic signalling, ATF6and PERK. CHOP being the major regulator of Bcl2, Bim and DR5 leads to cellularapoptosis preventing tumour progression (Krajarng et al. 2015).
GAMBOGIC ACID 준비 용품 및 원자재
원자재
준비 용품
GAMBOGIC ACID 공급 업체
글로벌( 226)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3777 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 |
sales@chemnorm.com | CHINA | 2935 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
GAMBOGIC ACID 관련 검색:
4'-Hydroxynonanophenone
4-Hexanoylresorcinol
6-METHYL-4-CHROMANONE
GAMBOGIC ACID
2-ETHOXYCYCLOHEXANONE
3,7-DIMETHYL-2-METHYLENE-OCT-6-ENAL
2,2,5,5-TETRAMETHYLTETRAHYDROFURAN
2,2-DIMETHYL-CHROMAN-4-ONE
2-ETHYL-2-METHYL-CHROMAN-4-ONE
CHEMBRDG-BB 6484841
5-HYDROXY-2,2-DIMETHYL-2H-CHROMENE-6-CARBALDEHYDE
5,7-dihydroxy-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one
CHEMBRDG-BB 6571093
CHEMBRDG-BB 4021965
3-(3,5-DIMETHYL-4-METHOXYPHENYL)-2-METHYL-1-PROPENE
7-METHOXY-2,2-DIMETHYL-3-CHROMENE
DIHYDROSORBICILLIN
7-HYDROXY-2,2-DIMETHYL-CHROMAN-4-ONE