ChemicalBook >제품 카탈로그 >TAK-220

TAK-220

TAK-220 구조식 이미지

카스 번호:: 333994-00-6

상품명:: TAK-220

동의어(영문):: TAK-220;TAK 220;TAK220;1-ACETYL-N-(3-(4-(4-CARBAMOYLBENZYL)PIPERIDIN-1-YL)PROPYL)-N-(3-CHLORO-4-METHYLPHENYL)PIPERIDINE-4-CARBOXAMIDE;4-Piperidinecarboxamide, 1-acetyl-N-[3-[4-[[4-(aminocarbonyl)phenyl]methyl]-1-piperidinyl]propyl]-N-(3-chloro-4-methylphenyl)-

CBNumber:: CB13122935

분자식:: C31H41ClN4O3

포뮬러 무게:: 553.14

MOL 파일:: 333994-00-6.mol

속성

안전

용도

공급 업체 29

TAK-220 속성

녹는점: 166-167 °C(Solv: ethyl acetate (141-78-6); ethanol (64-17-5))

끓는 점: 757.8±60.0 °C(Predicted)

밀도: 1.208±0.06 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMSO: 용해될 수 있다

물리적 상태: 결정성 고체

산도 계수 (pKa): 16.16±0.50(Predicted)

색상: White to off-white

안전

TAK-220 C화학적 특성, 용도, 생산

개요

TAK-220 is an orally bioavailable antagonist of chemokine (C-C motif) receptor 5 (CCR5). It binds to CCR5 (IC₅₀ = 3.5 nM for the human receptor in CHO cells), but not CCR1, CCR2b, CCR3, CCR4, or CCR7. TAK-220 inhibits the binding of chemokine (C-C motif) ligand 5 (CCL5) and CCL3 to CCR5 (IC₅₀s = 3.5 and 1.4 nM, respectively) but does not inhibit binding of CCL4. It inhibits HIV-1 envelope-mediated membrane fusion in a macrophage (M-tropic) R5, but not in a T cell (T-tropic) X4, strain of HIV-1 (IC₅₀s = 0.42 and >1,000 nM, respectively). TAK-220 inhibits the replication of six strains of R5 HIV-1 clinical isolates (EC₉₀ overall mean = 13 nM) and the R5 JR-FL laboratory-adapted strain (EC₅₀ = 0.6 nM), but not of X4 HIV-1 clinical isolates or the X4 IIIB laboratory-adapted strain (EC₅₀s = >10,000 nM for both), in human peripheral blood mononuclear cells (PBMCs).

TAK-220 준비 용품 및 원자재

원자재

준비 용품

TAK-220 공급 업체

글로벌( 29)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30250	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3466	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29786	68
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12308	58