Dmt-2'fluoro-da(bz) amidite
|
|
Dmt-2'fluoro-da(bz) amidite 속성
- 저장 조건
- Inert atmosphere,Store in freezer, under -20°C
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 7.87±0.43(Predicted)
- 색상
- White to off-white
- InChIKey
- ZDIBABNMVQPXHU-JWQXGDSTNA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 그림문자(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 신호 어: | Warning | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
|
||||||||||||||||||||||||||||
| 예방조치문구: |
|
Dmt-2'fluoro-da(bz) amidite C화학적 특성, 용도, 생산
Synthesis
3-((Bis(diisopropylamine)phosphanyl)oxy)propanenitrile (6.42 g, 21.3 mmol, 6.77 mL, 1.8 eq) was added to a solution of N-(9-((2R,3R,4R,5R)-5-((bis(4- methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H- purine-6-yl)benzamide (8.0 g, 11.8 mmol, 1.0 eq) in DCM (42 mL) at 0 °C followed by DCI (2.24 g, 18.9 mmol, 1.6 eq). The mixture was warmed to 25 °C and stirred for 3 hours. Two parallel reactions were carried out. The combined remedies were then diluted with DCM (150 mL), the organic layer was washed with sat NaHCO3 solution (200 mL) and brine (100 mL), dried over Na2SO4, filtered and concentrated, the crude was purified by column chromatography to give Dmt-2'fluoro-da(bz) amidite (18.0 g, 18.5 mmol, 78.1% yield, 90% purity) as a white solid.
Dmt-2'fluoro-da(bz) amidite 준비 용품 및 원자재
원자재
준비 용품
Dmt-2'fluoro-da(bz) amidite 공급 업체
글로벌( 138)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +undefined17756524438 |
sales1@nuowei-chem.com | China | 1640 | 58 |
| Hefei Huana Biomedical Technology Co.,Ltd. | +86-15900695956 |
shiqin.he@huanaok.com.cn | China | 96 | 58 |
| Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 |
yunbiochem@126.com | China | 321 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16221 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10259 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 5738 | 58 |
| NINGBOBENKANGJS PHARMTECHCO., LTD | +8615990591583 15990591583 |
CHINA | 2029 | 58 | |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 |
info@finetechnology-ind.com | China | 9626 | 58 |