This Mitragyna alkaloid has been isolated from the leaves of M. speciosa Korth
by Beckett and his colleagues. It is an amorphous solid which cannot be obtained
crystalline. The base may be characterized as the picrate which forms pale yellow
needles from MeOH, m.p. 223°C (dec.). A methylgroup, a methoxycarbonyl
group and one imino group are present. The second nitrogen atom is tertiary.
생물학적 활성
Isomitraphylline, an oxindole alkaloid, has potent anti-cancer activity.
참고 문헌
Beckett et al., J. Pharm. Pharmacol., 17,753 (1965)
Beckett et ai., Planta Med., 14, 266 (1966)
Structure:
Finch, Taylor., J. Amer. Chem. Soc., 84,3871 (1962)
Prepara tion:
Seaton et al., Can. J. Chem., 38, 1035 (1960)
