락토페리신

락토페리신 C화학적 특성, 용도, 생산

개요

Lactoferrin, a granule-associated glycoprotein, is a cationic protein with a high proportion of arginine and lysine at the N-terminal region, with two glycosylation and several iron-binding sites. Lactoferrin is highly antibacterial against both gram-positive and gram-negative bacteria at concentrations ranging from 3 to 50 μg/ml. It is believed that these lethal effects are due to a direct interaction of lactoferrin with the cell surface and subsequent disruption of normal permeability functions of the membrane, a so-called dissipation of proton motive force action (23). Similarly, expression of an antimicrobial tachyplesin gene from Asian horseshoe crabs led to antibacterial activity against Erwinia spp. in transgenic potato (24).

용도

Lactoferrin was used in the fractionation of lactoperoxidase and lactoferrin from bovine whey using a cation exchange membrane. It was used in the determination of lactoferrin and immunoglobulin G in animal milks by new immunosensors.

생물학적 활성

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

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공급자	전화	이메일	국가	제품 수	이점
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3791	58
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177; +8617531190177	peter@yan-xi.com	China	5873	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5867	58
Suzhou Sanyi Polymer Chemical Technology Co., Ltd.	+8615571922873	15571922873@163.com	China	106	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10991	58
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Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	1143	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+8615383190639	admin@86-ss.com	China	1000	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21667	55

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