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(S,R,S)-AHPC-PEG6-Azide

(S,R,S)-AHPC-PEG6-Azide 구조식 이미지

카스 번호:: 2086298-71-5

상품명:: (S,R,S)-AHPC-PEG6-Azide

동의어(영문):: (S,R,S)-AHPC-PEG6-Azide;(S,R,S)-AHPC-PEG₆-Azide;(2S,4R)-1-((S)-23-azido-2-tert-butyl-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosane)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-23-Azido-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-2-(20-azido-3,6,9,12,15,18-hexaoxaicosanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-23-Azido-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker-E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate

CBNumber:: CB18362273

분자식:: C36H55N7O10S

포뮬러 무게:: 777.94

MOL 파일:: 2086298-71-5.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 11

(S,R,S)-AHPC-PEG6-Azide 속성

저장 조건: 2-8°C

물리적 상태: (Liquid or Semi-Solid or Paste or Solid)

안전

(S,R,S)-AHPC-PEG6-Azide C화학적 특성, 용도, 생산

용도

Protein degrader builiding block (S,R,S)-AHPC-PEG₆-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with an alkyne on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

(S,R,S)-AHPC-PEG6-Azide 준비 용품 및 원자재

원자재

준비 용품

(S,R,S)-AHPC-PEG6-Azide 공급 업체

글로벌( 11)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Xian confluore Biological Technology Co., Ltd.	+86-15680926068	1924344760@confluore.cn	China	2997	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4841	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1593	58
Shanghai Haohong Pharmaceutical Co., Ltd.	400-8210725 4008210725	malulu@leyan.com	China	55000	58
Zhengzhou convergence chemical co., LTD	0371-0371-55153829 18003835034	2853979819@qq.com	China	9866	58
Wuhan Yuxiang Medical Technology Co., Ltd.	13971275651	sales@whyxpharma.com	China	1943	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	9070	58
Shanghai Yanfen Biochemical Technology Co.,LTD	13611955358	yanfen2024@126.com	China	1876	58