NeoCide PC-150 Preservative is a widely used raw materials used in IVD products list for control of microbial growth and biofouling. The active ingredient is a 3:1 ratio of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-methyl-4 isothiazolin - 3-one (MIT). It exhibits outstanding antimicrobial activity against bacteria, mold and yeast even algae. This preservative is stable and effective over a wide range of pH, however it is generally more stable over the lifetime of the reagent at acid environment (pH<7) . The stability of the preservative is reduced and sensitive to temperature in mildly alkaline(pH<8.5). When the IVD products pH exceeds 9 and do not recommend the application since it is not stable in the environment of strong alkaline.