ANTI-RUNX1;Anti-MDS1-EVI1;Anti-MGC163392;ANTI-CORE-BINDING FACTOR ALPHA2;Anti-RUNX1 antibody produced in rabbit;Anti-Ecotropic viral integration site 1;ANTI-RUNT-RELATED TRANSCRIPTION FACTOR 1;Anti-CBF-α 2 antibody produced in rabbit;Anti-PEA2-α B antibody produced in rabbit;Anti-PEBP2-α B antibody produced in rabbit
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Western Blotting (1 paper)
일반 설명
Runt-related transcription factor 1 (RUNX1) is a transcription factor that crucially performs in hematopoiesis, osteogenesis and neurogenesis. It is a member of Runt-related transcription factors (RUNXs). It was first identified as a component of Moloney murine leukemia virus enhancer core binding factor (CBF) and Polyomavirus enhancer binding protein 2 (PEBP2). Three isoforms of the protein have been identified: RUNX1a, RUNX1b and RUNX1c. Structurally, it consists of Runt domain at the N-terminal region.
Biochem/physiol Actions
In addition to the regulatory effects in hematopoiesis, osteogenesis and neurogenesis, RUNX1 also plays a vital role in tumour suppression and oncogenic activities. In hematopoiesis, it performs in hematopoietic development, hematopoietic stem cell homeostasis, and various blood malignancies. It may have clinicopathological impact on the proliferation of human bone marrow cells for use in transplantation therapy.
