ChemicalBook >제품 카탈로그 >4-(클로로메탄)-2-메틸히드리딘

4-(클로로메탄)-2-메틸히드리딘

4-(클로로메탄)-2-메틸히드리딘 구조식 이미지

카스 번호:: 75523-42-1

한글명:: 4-(클로로메탄)-2-메틸히드리딘

동의어(한글):: 4-(클로로메탄)-2-메틸히드리딘

상품명:: 4-(CHLOROMETHYL)-2-METHYLPYRIDINE

동의어(영문):: 4-(Chloromethyl)-2-picoline;2-Methyl-4-(chloromethyl)pyridine;4-(CHLOROMETHYL)-2-METHYLPYRIDINE;pyridine, 4-(chloroMethyl)-2-Methyl-;4-Chloromethyl-2-methyl-pyridine.HCL;2-methyl-pyridin-4-ylmethyl chloride;2-Methyl-4-(chloromethyl)pyridine (HCl)

CBNumber:: CB22454432

분자식:: C7H8ClN

포뮬러 무게:: 141.6

MOL 파일:: 75523-42-1.mol

속성

안전

용도

공급 업체 28

4-(클로로메탄)-2-메틸히드리딘 속성

끓는 점: 218℃

밀도: 1.118

인화점: 106℃

안전

4-(클로로메탄)-2-메틸히드리딘 C화학적 특성, 용도, 생산

용도

4-Chloromethyl-2-methylpyridine is used in the preparation of HIV-1 protease inhibitors.

Synthesis

4-(Chloromethyl)-2-methylpyridine is synthesised using (2-Methylpyridin-4-yl)methanol as a raw material by chemical reaction. The specific synthesis steps are as follows:
5-[(2-Chlorophenyl)acetylamino]-3-(4-fluorophenyl)-4-[4-(2-methylpyridyl)]isoxazole a) 4-Chloromethyl-2-methylpyridine; Into 100 mL of methylene chloride solution containing 2. 1-6 g of 4-(2-methylpyridyl)methanol (cf. PCT International Publication WO98/2120 Pamphlet), 23 mL of thionyl chloride was dropped at room temperature, followed by 20 hours' stirring at room temperature. The solvent was distilled off from the reaction solution under reduced pressure, and the residue was extracted with methylene chloride, after addition of saturated aqueous NaHCO3 solution. The methylene chloride extract was dried over anhydrous magnesium sulfate, and from which the solvent was distilled off under reduced pressure to provide 2.46 g (yield: 100%) of brown crystalline title compound. 1H-NMR(CDCl3)delta:8.45(d,J=5.0Hz,1H),7.31(s,1H), 7.25(d,J=5.0Hz,1H),4.74(s,2H),2.48(s,3H) Mass,m/e:141 (M+,base).
4-(Chloromethyl)-2-methylpyridine synthesis

4-(클로로메탄)-2-메틸히드리딘 준비 용품 및 원자재

원자재

준비 용품

4-(클로로메탄)-2-메틸히드리딘 공급 업체

글로벌( 28)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30253	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Terma Medicare India Pvt.,Ltd	+8613916485955	shivshanghai@yahoo.com	India	145	58
Cochemical Co. Ltd.	+86-029-86115547 +86-17791676824	sales@cochemical.com	China	3953	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94717	76
Hangzhou Sage Chemical Co., Ltd.	+86057186818502 13588463833	info@sagechem.com	China	10269	58
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8073	58
Changzhou Hopschain Chemical Co.,Ltd.	0519-85528066 13775048983	sales@hopschem.com	China	31557	55

4-(클로로메탄)-2-메틸히드리딘 관련 검색:

2-CHLORO-6-METHYLPYRIDINE-4-CARBONYL CHLORIDE 4-(CHLOROMETHYL)-2-METHYLPYRIDINE 4-QUINOLINECARBONYL CHLORIDE,6-CHLORO-2-PHENYL- Quinoline, 4-(chloromethyl)-2-methyl- (9CI) 2-Phenylquinoline-4-carboxylicacidchloride 6-bromo-2-phenylquinoline-4-carbonyl chloride 4-(CHLOROMETHYL)PYRIDINE-2-CARBONITRILE ETHYL 4-(CHLOROMETHYL)PYRIDINE-2-CARBOXYLATE 4-(CHLOROMETHYL)-2-PHENYLPYRIDINE 4-DICHLOROMETHYL-6-METHYL-2-PHENYL-QUINOLINE 4-[CHLORO(DIFLUORO)METHYL]-2-HYDROXY-6-[4-(TRIFLUOROMETHYL)PHENYL]NICOTINONITRILE 4-DICHLOROMETHYL-2-PHENYL-QUINOLINE 4-(CHLOROMETHYL)-2-(3,4,5-TRIMETHOXYPHENYL)PYRIDINE 4-(CHLOROMETHYL)-2-(4-FLUOROPHENYL)PYRIDINE 2-PHENYL-QUINOLINE-4-CARBONYL CHLORIDE HYDROCHLORIDE 4-[CHLORO(DIFLUORO)METHYL]-2-HYDROXY-6-METHYLNICOTINONITRILE 2,4-BIS(TRICHLOROMETHYL)-7-CHLOROQUINOLINE 2,4-BIS(TRICHLOROMETHYL)QUINOLINE