ChemicalBook >제품 카탈로그 >(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione 구조식 이미지

카스 번호:: 92395-41-0

상품명:: (7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione

동의어(영문):: Amrubicin intermediate;Amrubicin Intermediate 5;Amrubicinhydrochloride int5;9α-amino-9β-acetyl-7,8,9,10-tetrahydro-6,7α,11-trihydroxy-5,12-naphthacenedione;(7S,9S)-9-Acetyl-9-amino-6,7,11-trihydroxy-7,8,9,10-tetrahydro-5,12-tetracenedione;(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione;5,12-Naphthacenedione, 9-acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-, (7S,9S)-

CBNumber:: CB22717140

분자식:: C20H17NO6

포뮬러 무게:: 367.35

MOL 파일:: 92395-41-0.mol

속성

안전

용도

공급 업체 14

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione 속성

녹는점: 158-159℃

끓는 점: 604.6±55.0 °C(Predicted)

밀도: 1.550±0.06 g/cm3(Predicted)

산도 계수 (pKa): 7.92±0.60(Predicted)

안전

HS 번호	2922500090

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione C화학적 특성, 용도, 생산

용도

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione can be used as organic synthesis intermediates and pharmaceutical intermediates. It is an intermediate in the synthesis of amrubicin. amrubicin is a third-generation synthetic anthracycline currently in development for the treatment of small cell lung cancer.

Synthesis

A mixture of R-9-acetamido-9- [1,1- (2,2-dimethylpropanedioxy) ethyl] -4,5-dihydro-6,13-dihydroxy -4,14- Methyl-14H-anthraceno [3,2-f] - [1,3] oxazolene-7,12-dione (Compound 4, R = CH3), 1200 g of 3N sulfuric acid aqueous solution and incubated at 60-70 ?? C for 8 hours. The pH of the solution was adjusted to 7-8 with aqueous sodium hydrogencarbonate solution, The combined chloroform layers were washed with water, dried, filtered and concentrated. The residue was stirred with isopropyl ether to give (+) - 9-amino-4-demethoxy-9-deoxo daunomycinone.

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione 준비 용품 및 원자재

원자재

5,8-디메톡시-2-테트라론

준비 용품

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione 공급 업체

글로벌( 14)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	801	55
Sense Chemicals (Shanghai) Co., Ltd.	+86-21-52751036; +8613818977689	david.dai@sensechemicals.com	China	225	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
Hebei Guanlang Biotechnology Co., Ltd.	+8619930503259	cherry@crovellbio.com	China	18433	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10978	58
Wuhan EEChem Technologies Co., Ltd	0711-3617768 13308685235	lihongcai4360@sina.com	China	1379	55
Abydos Scientific	025-84767922 18936879710	sales@abydoscientific.com	China	1009	58
Speranza Chemical Co., Ltd.	0755-21030354 18126410231	sales@speranzachem.com	China	511	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18488	58
WEITIXIHAUGONG	0371-53370800 18037197114	2853031799@qq.com	China	10010	58