TAPI-1
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TAPI-1 속성
- 밀도
- 1?+-.0.06 g/cm3(Predicted)
- 저장 조건
- -20C
- 용해도
- ≥24.98 mg/mL in DMSO; ≥15.77 mg/mL in EtOH with ultrasonic; ≥18.1 mg/mL in H2O
- 물리적 상태
- 흰색 고체
- 산도 계수 (pKa)
- 9.17±0.20(Predicted)
- 색상
- White to off-white
안전
TAPI-1 C화학적 특성, 용도, 생산
일반 설명
A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-α, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC50 = 8.09 μM) and muscarinic receptor-stimulated (IC50 = 3.61 μM) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC50 = 920 nM).Biochem/physiol Actions
Primary TargetMMPs and TACETAPI-1 준비 용품 및 원자재
원자재
준비 용품
TAPI-1 공급 업체
글로벌( 56)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 |
sales@alphabiopharm.com | China | 992 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32957 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 |
sales@nextpeptide.com | China | 19908 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38631 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131957 | 58 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 |
meilunui@163.com | China | 4727 | 58 |