CK 869;CK-869;CS-2870;CK-0157869;CK-869; CK 869; CK869; CK-0157869; CK 0157869; CK0157869;2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone;2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)thiazolidin-4-one;4-Thiazolidinone, 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-;CK869,Arp2/3 Complex,inhibit,CK-869,Inhibitor,CK 869,Actin-related protein 2/3 complex
장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴
특정 표적장기 독성 - 반복 노출
구분 1
위험
P260, P264, P270, P314, P501
H410
장기적 영향에 의해 수생생물에 매우 유독함
수생 환경유해성 물질 - 만성
구분 1
경고
P273, P391, P501
예방조치문구:
P201
사용 전 취급 설명서를 확보하시오.
P264
취급 후에는 손을 철저히 씻으시오.
P264
취급 후에는 손을 철저히 씻으시오.
P280
보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P330+P331
삼켰다면 입을 씻어내시오. 토하게 하려 하지 마시오.
P312
불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
CK-0157869 C화학적 특성, 용도, 생산
개요
CK 869 is an inhibitor of actin polymerization via inhibition of the actin-related protein 2/3 (Arp2/3) complex, leading to reduced cell motility rate and rearrangement of F-actin in M-1 cells. It inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 μM. It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells.
용도
CK-869 binds to the Arp2/3 complex and inhibits nucleation. The Arp2/3 complex is involved with cell motility and F-actin reorganization in M-1 cells.
Biochem/physiol Actions
CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.
