PAROMOMYCIN SULFATE
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PAROMOMYCIN SULFATE 속성
- 녹는점
- 145 °C (decomp)
- 알파
- D25 +50.5° (c = 1.5 in water pH 6)
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- H2O: 50 mg/mL。 원액을 2~8°C에 보관하세요. 37°C에서 5일 동안 안정합니다.
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- 물에 용해됨
- Merck
- 14,7041
- BRN
- 5715182
- 안정성
- 흡습성
- InChIKey
- LJRDOKAZOAKLDU-UDXJMMFXSA-N
- CAS 데이터베이스
- 1263-89-4
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
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위험 카페고리 넘버 | 23/24/25-36/38-39/23/24/25-61-36/37/38 | ||
안전지침서 | 26-36/37-45-38-36 | ||
WGK 독일 | 2 | ||
RTECS 번호 | WK2320000 | ||
HS 번호 | 2941901010 | ||
독성 | LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli) | ||
기존화학 물질 | KE-01281 |
그림문자(GHS): | |||||||||||||||||||||||||||||
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신호 어: | Warning | ||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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PAROMOMYCIN SULFATE C화학적 특성, 용도, 생산
개요
Paromomycin was found in the culture broth of Streptomyces rimosus forma paromomycinus by Parke Davis & Co. in 1959. In the same year it was found in the culture broth of S. Crestomyceticus by Farmitalia and named amminosidin. Paromomycin is related structurally to neomycin, but it has a hydroxyl group at the 6 position, whereas neomycin has an amino group. Its antibacterial activity is weaker than that of neomycin, but its toxicity is much less. Paromomycin is used by intramuscular injection for therapy of respiratory, urinary, and surgical infections and by oral administration to treat dysentery and salmonellosis.화학적 성질
PAROMOMYCIN SULFATE is White to Off-White Solid용도
PAROMOMYCIN SULFATE is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed addit ive in turkey poults experimentally infected with Histomonas meleagridis.정의
ChEBI: An aminoglycoside sulfate salt resulting from the treatment of paromomycin with sulfuric acid. A broad-spectrum antibiotic, it is used for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoa infections. It is also used as a therapeutic against visceral leishmaniasis.일반 설명
Chemical structure: aminoglycosideClinical Use
The isolation of paromomycin (Humatin) was reported in1956 from a fermentation with a Streptomyces sp. (PD04998), a strain said to resemble S. rimosus very closely.The parent organism had been obtained from soil samplescollected in Colombia. Paromomycin, however, moreclosely resembles neomycin and streptomycin in antibioticactivity than it does oxytetracycline, the antibiotic obtainedfrom S. rimosus.Paromomycin has broad-spectrum antibacterial activityand has been used for the treatment of GI infections causedby Salmonella and Shigella spp., and enteropathogenic E.coli. Currently, however, its use is restricted largely to thetreatment of intestinal amebiasis. Paromomycin is soluble inwater and stable to heat over a wide pH range.
Safety Profile
Poison by intravenous,subcutaneous, and intramuscular routes. Mildly toxic byingestion. Mutation data reported. When heated to decomposition it emits very toxic fumesof SOx and NOx.Purification Methods
Purify it by dissolving it in H2O (0.5g/10mL) and adding excess EtOH, filter or collect and wash with EtOH, then Et2O by centrifugation, and dry it in vacuo. An aqueous solution is stable at 37o for a week but longer at 0-5o. The free base [7542-37-2] is a white amorphous powder which should be stored under N2 because it is strongly basic and can absorb CO2 from the atmosphere. It is soluble in MeOH (less soluble in EtOH) and has [] D 25 +65o (c 1.5, MeOH). It is an antimicrobial against Gram +ve and Gram –ve bacteria and is antiamoebic. It inhibits initiation and peptide elongation during protein synthesis. [Haskell et al. J Am Chem Soc 8 1 , 3480, 3482 1959, Hichens & Rinehart J Am Chem Soc 85 1547 1963, Beilstein 18 III/IV 7534.]PAROMOMYCIN SULFATE 준비 용품 및 원자재
원자재
준비 용품
PAROMOMYCIN SULFATE 공급 업체
글로벌( 346)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12460 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 |
peter@yan-xi.com | China | 6011 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9338 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29897 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8827 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 |
faith@widelychemical.com | CHINA | 742 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
PAROMOMYCIN SULFATE 관련 검색:
스펙티노마이신 디수화염화물
Nitazoxanide
Spiramycin
Rimonabant
Ribostamycin sulfate
(R)-2-Aminocyclohenanol
Glucosamine sulfate
PAROMOMYCIN SULFATE
C-(TETRAHYDRO-PYRAN-2-YL)-METHYLAMINE HYDROCHLORIDE
paromomycin
5-Deoxy-D-ribose
Methyl beta-D-ribofuranoside
TRANS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE
3-BUTOXY-PROPIONALDEHYDE DIETHYL ACETAL
3-Amino-cyclohexanol
{PAROMOMYCIN SULFATE--N/H
PAROMOMYCIN SULFATE USP(CRM STANDARD)
PAROMOMYCIN SULFATE WHO(CRM STANDARD)