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MRT67307

MRT67307 구조식 이미지

카스 번호:: 1190379-70-4

상품명:: MRT67307

동의어(영문):: MRT68921(HCI);MRT68921(HCl);MRT68921 (free base);MRT68921;MRT-68921;MRT 68921;N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)prop;N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide;N-(3-((5-cyclopropyl-2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide;Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-

CBNumber:: CB23043299

분자식:: C25H34N6O

포뮬러 무게:: 434.58

MOL 파일:: 1190379-70-4.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 42

MRT67307 속성

저장 조건: Store at -20°C

용해도: insoluble in H2O; insoluble in EtOH; ≥2.18 mg/mL in DMSO with gentle warming and ultrasonic

물리적 상태: 결정성 고체

색상: Light yellow to yellow

안전

MRT67307 C화학적 특성, 용도, 생산

개요

MRT68921 is an inhibitor of ULK1 and ULK2 (IC₅₀s = 2.9 and 1.1 nM, respectively). Through its effects on ULK1, MRT68921 blocks autophagy in cells, driving the accumulation of stalled early autophagosomal structures.

용도

MRT68921 dihydrochloride has been used:

as a specific inhibitor of Unc-51-like kinase 1 (ULK1) in SH-SY5Y neuroblastoma cells
as an inhibitor of ULK1 and ULK2 kinases in intrahepatic lymphocytes
as a ULK1 inhibitor to test its effect on attenuation of autophagosome accumulation in ubiquitin-specific peptidase 24 (USP24)?knockdown containing human neuroglioma H4 cells

Biochem/physiol Actions

MRT68921 is cytotoxic and acts on oxidative stress signals to kill cancer cells, making it an effective tumor therapy agent.

MRT67307 준비 용품 및 원자재

원자재

준비 용품

MRT67307 공급 업체

글로벌( 42)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29826	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Topbiochem Technology Co., Ltd	021-58170097	info@topbiochem.com	China	9461	58
TargetMol Chemicals Inc.	021-021-33632979 15002134094	marketing@targetmol.com	China	7854	58