에틸-2,2-디메틸-7-브로모헵타노에이트
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에틸-2,2-디메틸-7-브로모헵타노에이트 속성
- 끓는 점
- 106-108 °C(Press: 0.01 Torr)
- 밀도
- 1.169±0.06 g/cm3(Predicted)
- InChI
- InChI=1S/C11H21BrO2/c1-4-14-10(13)11(2,3)8-6-5-7-9-12/h4-9H2,1-3H3
- InChIKey
- SYRIIFZUZOIRNU-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)C(C)(C)CCCCCBr
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
HS 번호 | 2915907098 |
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그림문자(GHS): |
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신호 어: | Warning | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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에틸-2,2-디메틸-7-브로모헵타노에이트 C화학적 특성, 용도, 생산
개요
Ethyl 7-bromo-2,2-dimethylheptanoate is an important raw material in the synthesis route of bepetidic acid. Bempedoic acid, whose chemical name is 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid, also known as ETC-1002, is a new type of lipid developed by the American EsperionTherapeutic company Quality regulation small molecule drugs. As one of the company's main drug candidates, its targets are liver adenosine triphosphate-citrate lyase (ACL) and adenosine monophosphate-activated protein kinase (AMPK).용도
Ethyl-2,2-dimethyl-7-bromoheptanoate can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and chemical production processes.Synthesis
![Synthesis_123469-92-1](/NewsImg/2021-12-01/6377397377223851566190974.jpg)
The specific embodiment of the present invention is as follows: prepare 19.4g (167mmol) of ethyl isobutyrate in 216mL solution of tetrahydrofuran with a mass concentration of 10%, connect to metering pump 1; prepare 84mL (168mmol) of 2.0M n-butyllithium solution, connect to meter Pump 2; configure 1,5-dibromopentane 80.0g (348mmol) tetrahydrofuran 100mL solution, mass concentration is 63%, connected to metering pump 3.Configure 300mL of 1N hydrochloric acid solution and connect to metering pump 4.Set continuous flow precooler 1, the circulating temperature is 0, and reach stability; set continuous flow precooler 2, the circulating temperature is 0, and reach stability; set continuous flow precooler 3, and the circulating temperature is 0, and reach stability; set continuous flow precooler 4, cycle temperature is 0, and reach stability;Set the flow rate of metering pump 1 to 65.0ml/min, set the flow rate of metering pump 2 to 25.0ml/min, set the flow rate of metering pump 3 to 30.0ml/min, and set the flow rate of metering pump 4 to 90.0ml/min.Turn on the metering pump 1 and metering pump 2 at the same time. After 60s of operation, turn on the metering pump 3, and after 60s of operation, turn on the metering pump 4 to collect the outflowing reaction liquid in the storage tank.After the operation is completed, separate the liquids, collect the upper organic phase, concentrate under reduced pressure at P=-0.08MPa, T=45??C to remove low-boiling solvents, and then rectify under reduced pressure at P=5mmHg and T=70??C to obtain 38.4 g.The obtained product is a colorless liquid with a GC purity of 98.6% and a yield of 87%.
에틸-2,2-디메틸-7-브로모헵타노에이트 준비 용품 및 원자재
원자재
준비 용품
에틸-2,2-디메틸-7-브로모헵타노에이트 공급 업체
글로벌( 155)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 7353 | 58 |
weifang runzhong fine chemical co., ltd | 536-7868377 +8618653686003 |
sq@runzhongchem.com | China | 187 | 58 |
AstaTech(Chengdu) Biopharmaceutical Corp. | +86-02882666559 +86-15884417729 |
gjpu@astatech.com.cn | China | 308 | 58 |
Shanghai Famo Biotech Co Ltd | +8618550473860 |
mayan@famobiotech.com | China | 513 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20314 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 |
sophieliu@speranzachem.com | China | 788 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29826 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 13056 | 58 |