퀴놀린
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퀴놀린 속성
- 녹는점
- -17--13 °C (lit.)
- 끓는 점
- 113-114 °C/11 mmHg (lit.) 237 °C (lit.)
- 밀도
- 1.093 g/mL at 25 °C (lit.)
- 증기 밀도
- 4.5 (vs air)
- 증기압
- 0.07 mm Hg ( 20 °C)
- 굴절률
- n
20/D 1.625(lit.)
- 인화점
- 214 °F
- 저장 조건
- Store below +30°C.
- 용해도
- 6g/L
- 물리적 상태
- 액체
- 산도 계수 (pKa)
- 4.9(at 20℃)
- 색상
- 보라색에서 진한 회색까지
- 냄새
- 강하고 불쾌합니다.
- 수소이온지수(pH)
- 7.3 (5g/l, H2O, 20℃)
- 폭발한계
- 1.2-7%(V)
- ?? ??
- 약용
- 수용성
- 약간 용해됨
- 감도
- Light Sensitive & Hygroscopic
- Merck
- 14,8068
- BRN
- 107477
- Dielectric constant
- 2.6(-180℃)
- 안정성
- 안정적인. 강산, 강산화제와 호환되지 않습니다. 빛에 노출되면 변색될 수 있습니다. 흡습성 - 습기로부터 보호합니다. 일부 물질, 특히 강한 산화제와 격렬하고 예측할 수 없게 반응합니다.
- InChIKey
- SMWDFEZZVXVKRB-UHFFFAOYSA-N
- LogP
- 2.04 at 22℃
- CAS 데이터베이스
- 91-22-5(CAS DataBase Reference)
- IARC
- 2B (Vol. 121) 2019
- NIST
- Quinoline(91-22-5)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,N,T | ||
---|---|---|---|
위험 카페고리 넘버 | 21/22-38-41-68-40-37/38-51/53-36/38-45 | ||
안전지침서 | 26-36/37/39-36-23-61-45-53 | ||
유엔번호(UN No.) | UN 2656 6.1/PG 3 | ||
WGK 독일 | 2 | ||
RTECS 번호 | VA9275000 | ||
F 고인화성물질 | 8 | ||
자연 발화 온도 | 896 °F | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | III | ||
HS 번호 | 29334900 | ||
유해 물질 데이터 | 91-22-5(Hazardous Substances Data) | ||
독성 | LD50 orally in rats: 460 mg/kg (Smyth) | ||
기존화학 물질 | KE-02719 | ||
유해화학물질 필터링 | 2013-1-667 | ||
중점관리물질 필터링 | 별표1-38 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 퀴놀린 및 0.1% 이상 함유한 혼합물 |
퀴놀린 C화학적 특성, 용도, 생산
용도
알칼로이드· 퀴놀린 염료 등의 합성원료가 되며, 미량 중금속이온의 정량분석 시약으로도 사용된다.화학적 성질
Quinoline is a colorless liquid with a penetrating amine odor. Turns brown on exposure to light.출처
Quinoline was discovered in coal tar distillate in 1834 by Runge. It is released to the environment through natural combustion processes and has been isolated from air particulates (Dong et al 1977). Quinoline may be a significant aqueous byproduct of synthetic fuel production (shale oil, coal processing) and from wood preservation production and use facilities. Small amounts also have been detected in tobacco smoke (Schmeltz and Hoffmann 1977).용도
Quinoline is used in the manufacture of dyesand hydroxyquinoline salts; as a solvent forresins and terpenes; and therapeutically as anantimalarial agent. It occurs in coal tar insmall amounts.생산 방법
Quinoline may be synthesized by heating aniline with glycerol and nitrobenzene in sulfuric acid (Skraup method) or by reacting aniline, acetaldehyde, and a formaldehyde hemiacetal (Windholz et al 1983). Commercial production is by isolation from coal tar with greater than 100,000 lbs being produced in 1977. Production of refined quinoline has almost ceased due to low demand (Parris et al 1983).정의
ChEBI: The simplest member of the quinoline class of compounds, comprising a benzene ring ortho fused to C-2 and C-3 of a pyridine ring.일반 설명
A colorless liquid with a peculiar odor. Slightly denser than water. Contact may irritate to skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals.공기와 물의 반응
Hygroscopic. Soluble in water.반응 프로필
Quinoline is hygroscopic. Quinoline absorbs as much as 22% water. Quinoline is sensitive to light and moisture. Quinoline darkens on storage. Quinoline is a weak base. A potentially explosive reaction may occur with hydrogen peroxide. Quinoline reacts violently with dinitrogen tetraoxide. Quinoline also reacts violently with perchromates. Quinoline is incompatible with (linseed oil + thionyl chloride) and maleic anhydride. Quinoline is also incompatible with strong oxidizers and strong acids. Quinoline can be unpredictably violent. Quinoline dissolves sulfur, phosphorus and arsenic trioxide. Quinoline may attack some forms of plastics. Quinoline is a preparative hazard.건강위험
No industrial injuries from quinoline exposure have been reported. Handling precautions similar to those taken for pyridine are recommended (EOHS 1971).Clinical signs of toxicity include lethargy, respiratory distress, and coma; cause of death is respiratory paralysis. Quinoline is a skin and eye irritant; it may cause permanent corneal injury (EOHS 1971).
Routine occupational exposure to quinoline probably constitutes low risk for acute toxicity. Long-term exposure to low concentrations may increase cancer risk.
화학 반응
Reactivity with Water No reaction; Reactivity with Common Materials: Attacks some forms of plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.공업 용도
Quinoline is used as a solvent for resins and terpenes. It also is used as an antimalarial, an antioxidant, a catalyst and as an intermediate in the manufacture of various products (Parris et al 1983).Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. Moderately toxic by skin contact. A skin and severe eye irritant. Mutation data reported. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. It can cause retinitis sdar to that caused by naphthalene but without causing opacity of the lens. Combustible when exposed to heat or flame. Its preparation has caused many industrial explosions. Potentially explosive reaction with hydrogen peroxide. Violent reaction with dmtrogen tetraoxide, perchromates. Incompatible with linseed oil + thionyl chloride, maleic anhydride, Unpredctably violent. When heated to decomposition it emits toxic fumes of NOx.잠재적 노출
In manufacture of quinoline deriva- tives (dyes and pesticides); in synthetic fuel manufacture. Occurs in cigarette smoke.Carcinogenicity
Liver tumors were observed in rats administered diets containing 0.05–0.25% quinoline. The incidence of hepatocellular carcinomas was 3/11 at 0.05%, 3/16 at 0.1%, and 0/19 at 0.25% versus 0/6 in controls. At 0.25%, most of the rats died within 40 weeks. The incidences of hemangioendotheliomas were 6/11, 12/16, 18/19, and 0/6, respectively. Hepatocellular carcinomas and hemangioendotheliomas were seen in livers of rats fed 500, 1000, or 2500 ppm for 16–40 weeks. Typical hyperplasias were also observed in the liver.환경귀착
biodegradative processes occur under aerobic conditions. Anaerobic degradation is minimal (Mill et al 1981). Breakdown of quinoline in natural waters has been correlated with bacterial concentration (Rogers et al 1984). Adsorption was high in acidic soils (pH<6) and low in basic soils (pH>7). The presence of pyridine decreased quinoline adsorption on acidic, but not basic, soils. Sorption did not correlate with organic carbon or clay content (Felice et al 1984). Soil bacteria have been grown with quinoline as the sole carbon source (Grant and Al-Najjar 1976). Quinoline did not bioconcentrate to a significant extent in fathead minnows (Southworth et al 1980).운송 방법
UN2656 Quinoline, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.비 호환성
Reacts, possibly violently, with strong oxidants, strong acids; perchromates, nitrogen tetroxide; and maleic anhydride. Keep away from moisture, steam, and light. Contact with hydrogen peroxide may cause explosion. Unpredictably violent, this substance has been the source of various plant accidents.폐기물 처리
Dissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.퀴놀린 준비 용품 및 원자재
원자재
준비 용품
2-Aminoquinoline
5-BROMOPYRIDINE-2,3-DICARBOXYLIC ACID
5-아미노인돌
4-NITROQUINOLINE N-OXIDE
1-메틸-5-니트로-1H-인돌
5-Bromo-6-chloronicotinic acid
모노질산 티아민
3-퀴놀린카르보니트릴
3,4-디메틸티에노[2,3-B]티오펜-2-카발데하이드
4-Vinylphenol
(R,S)-2-(4-이소프로필-4-메틸-5-옥소-2-이미다졸린-2-일)퀴놀린-3-카르복실릭 산
2-퀴놀린카르보니트릴
5-METHOXYBENZOFURAN-2-BORONIC ACID
4-METHOXYQUINOLINE
3-플루오로퀴놀린-4-카르복실산
4-Chloro-6-trifluoromethylpyrimidine
4-시아노스티렌
4-Aminoguinoline
2-Bromoquinoline
에리오크롬 블랙 T
2-히드록시퀴노린
C.I. 산성 노란색 3
4-니트로스티렌
옥신-구리
4-BROMO-2-(TRIFLUOROMETHYL)-5-METHOXYPYRIDINE
1-Benzothiophen-5-amine
3-아미노퀴누클리딘이염산염
퀴놀린산
퀴날딘산
2-Phenylquinoline
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
4-Hydroxy-3-methoxystyrene
8-Quinolinesulfonyl chloride
8-하이드록시퀴놀린
4-Bromoquinoline
염산싸이아민
3-메틸푸란
1-메틸-1,2,3,4-테트라히드로-퀴놀린-6-카르발데히드
Hexyl isocyanate
COMBRETASTATIN A-4
퀴놀린 공급 업체
글로벌( 444)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Auschemicals Pty Ltd | +61406202619 |
info@auschemicals.com | Australia | 431 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12495 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
Yujiang Chemical (Shandong) Co.,Ltd. | +86-17736087130 +86-18633844644 |
catherine@yjchem.com.cn | China | 983 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21663 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 |
info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8820 | 58 |