N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
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N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide 속성
- 끓는 점
- 714.8±60.0 °C(Predicted)
- 밀도
- 1.17±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO:100.0(Max Conc. mg/mL);214.3(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);107.15(Max Conc. mM)
- 산도 계수 (pKa)
- 15.39±0.46(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 투명한 흰색에서 밝은 갈색까지
안전
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide C화학적 특성, 용도, 생산
용도
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor used in pharmacological studies which showed that it underwent metabolic breakdown to RA-7 and showed pharmacological activities such as induced hypothermia in mice and showed optimal pharmacokinetics in rats.LP-211 is also a drug analogue of piperazinehexanamide exhibiting 5-HT7 receptor affinity.Biochem/physiol Actions
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide 준비 용품 및 원자재
원자재
준비 용품
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide 공급 업체
글로벌( 37)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32835 | 60 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 |
China | 4351 | 55 | |
Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 |
3008007409@qq.com | China | 27314 | 60 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 |
2853530910@QQ.com | China | 8014 | 62 |