(5S,8E,10E,12R)-12-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-5-hydroxy-15-(trimethylsilyl)-8,10-Pentadecadiene-6,14-diynoic acid 1-Methylethyl Ester is an intermediate in the synthesis of Resolvin E1 (R144690), an omega-3 polyunsaturated fatty acid derivative that exhibits potent anti-inflammatory, pro-resolution, and anti-nociceptive effects.