클로린E6
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클로린E6 속성
- 알파
- D20 -141° in acetone
- 저장 조건
- -20°C Freezer
- 용해도
- DMSO(약간), 이소프로판올(약간, 가열, 초음파 처리)에 용해됨
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 끓는 점
- 1093.7±60.0 °C(Predicted)
- 밀도
- 1.306±0.06 g/cm3(Predicted)
- 색상
- 검은색
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
HS 번호 | 2933998090 |
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클로린E6 C화학적 특성, 용도, 생산
개요
Chlorin E6 is a natural molecule and a promising photosensitizer. Chlorin E6 is isolated from renewable natural sources. Chlorin E6 is an attractive photodynamic therapy (PDT) drug candidate because of (1) its high absorption in the red spectral region, and (2) its low cost to make compared to other porphyrin-based PDT drugs. Chlorin E6 exhibits advantageous photophysical properties for PDT such as having long lifetimes in their photoexcited triplet states and high molar absorption in the red region of the visible spectrum. Moreover, a 664-nm laser light can penetrate tissue deeper that the 630-nm laser light used for other PDT drugs. Chlorin E6 is an important starting material for making PDT drug Talaporfin sodium (mono-L-aspartyl chlorin e6 or NPe6).PDT is currently being used as an alternative therapeutic modality for a variety of malignant tumors. Studies have examined antitumor activity of Ce6-induced PDT (Ce6-PDT) both in vitro and in vivo using a rat tumor models. In one study three-week-old male Sprague-Dawley (SD) rats were inoculated s.c. on the right flank with 5x106 RK3E-ras cells. The animals were administered i.v. with Ce6 (10 mg/kg) and 24 h later, PDT was performed using a laser diode at a light dose of 100 J/cm2. Ce6-PDT generated reactive oxygen species and led to significant growth inhibition in RK3E-ras cell. In addition, Ce6-PDT induced apoptosis through the activation of caspase-3 and its downstream target, PARP cleavage. The protein level of anti-apoptotic bcl-2 was also reduced by Ce6-PDT in RK3E-ras cells. In in vivo experiments, application of Ce6- PDT led to a significant reduction of tumor size. PCNA immunostaining and TUNEL assay revealed that Ce6-PDT inhibited tumor cell proliferation and increased apoptosis. (source: Oncology Reports, 2009, 22(5). 1085-1091.)
용도
Chlorin E6 is a photosensitizer.The conjugates of gold nanorods and chlorin e6 enhance the fluorescence detection and photodynamic therapy (PDT) of cancers.클로린E6 준비 용품 및 원자재
원자재
준비 용품
클로린E6 공급 업체
글로벌( 174)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 |
nutrabiotech@outlook.com | China | 300 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9268 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 19673 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14335 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29821 | 58 |
CHEMSOON CO.,LTD. | +8613761723174 |
sales01@chemsoon.com | China | 1211 | 58 |
클로린E6 관련 검색:
구리클로로필린나트륨 니켈 테트라페닐포르핀 5,10,15,20-테트라키스(4-메톡시페닐)-21H,23H-포르핀 코발트(II), 신테틱
5,10,15,20-tetra(m-hydroxyphenyl)chlorin
Vanadyl meso-tetraphenylporphine chlorin free
5,10,15,20-TETRAPHENYL-21H,23H-PORPHINE ZINC, LOW CHLORIN, SYNTHETIC
CHLORIN E6
TPP
MESO-TETRA(PENTAFLUOROPHENYL)PORPHINE CHLORIN FREE
PORPHINE
monoaspartyl chlorin e6
Chlorin e6 trisodium
diaspartyl chlorin e6
21H,23H-Porphine-7-propanoic acid, 3-carboxy-13-ethenyl-18-ethyl-7,8-dihydro-2,5,8,12,17-pentamethyl-, (7S,8S)-
CHLORIN E6 TRIMETHYL ESTER,3α,7,12,17-Tetramethyl-8-vinyl-13-ethyl-20-[(methoxycarbonyl)methyl]-18-(methoxycarbonyl)chlorin-2β-propionic acid methyl ester
meso-Tetraphenylporphine (1-3% chlorin)
Low-chlorin and high efficiency slushing agent
Low-chlorin and low-alkali slushing agent