9-CIS-레티노산
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9-CIS-레티노산 속성
- 녹는점
- 189-191°C
- 끓는 점
- 462.8±14.0 °C(Predicted)
- 밀도
- 1.011±0.06 g/cm3(Predicted)
- RTECS 번호
- VH6450000
- 저장 조건
- -20°C
- 용해도
- 아세토니트릴(매우 약간), 클로로포름(약간 용해됨), DMSO(약간 용해됨)
- 산도 계수 (pKa)
- 4.73±0.33(Predicted)
- 물리적 상태
- 연한 노란색에서 주황색의 결정성 분말.
- 색상
- 연한 노란색에서 노란색까지
- 수용성
- 클로로포름(50mg/ml), DMSO(~25mg/ml), 에탄올(25mg/ml) 및 아세톤(25mg/ml)에 용해됩니다. 물에 불용성.
- 감도
- Moisture & Light Sensitive
- 안정성
- 최대 1년 동안 -20°C의 냉장고에 보관하세요. 최대 3개월 동안 -20°C에서 용액에 보관하세요
- CAS 데이터베이스
- 5300-03-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T | ||
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위험 카페고리 넘버 | 61-36/37/38 | ||
안전지침서 | 53-26-36/37/39-45 | ||
WGK 독일 | 3 | ||
HS 번호 | 29162090 | ||
유해 물질 데이터 | 5300-03-8(Hazardous Substances Data) |
9-CIS-레티노산 C화학적 특성, 용도, 생산
개요
Alitretinoin was introduced in the US for the topical treatment of cutaneous lesions in patients with Kaposi's sarcoma (KS), the most frequent malignancy observed in AIDS patients. It is a derivative of 9-cis-retinoic acid (9- cis-RA) identified as an endogenous hormone in mammalian tissues. Alitretinoin binds to all isoforms of the intracellular retinoid X (RXR) and retinoid A (RAR) receptors thus inducing cell differentiation, increasing cell apoptosis and inhibiting cellular proliferation in experimental models of human cancer. In an international phase III trial in patients with KS, 42% of 82 patients treated with 0.1% gel formulation experienced complete or partial responses cf 7% for controls. Alitretinoin is the first topical therapy for KS and is expected to be a new option to its traditional management.화학적 성질
Pale Yellow Solid용도
9-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. 9-cis-Retinoic acid is an inhibitor of Cox-2 and an activator of RAR α, RAR β, RAR γ and RXR.Indications
Alitretinoin (Panretin) is a naturally occurring endogenous retinoid that binds to and activates all known retinoid receptors (both RARs and RXRs). It is approved for the topical treatment of cutaneous lesions of Kaposi’s sarcoma. Most patients have local irritation while using alitretinoin gel; however, the irritation rarely necessitates discontinuation of therapy.정의
ChEBI: A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.9-CIS-레티노산 준비 용품 및 원자재
원자재
준비 용품
9-CIS-레티노산 공급 업체
글로벌( 155)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12447 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9338 | 55 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 |
1015@dideu.com | China | 4088 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 13256 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 |
mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15395 | 58 |
9-CIS-레티노산 관련 검색:
레티노산 13-씨스-레티노산
4-KETO 13-CIS-RETINOIC ACID
9,13-retinoic acid
Isotretinoin EP Impurity C
11-cis Retinoic Acid
9-CIS-RETINOIC ACID
9-CIS-RETINAL
9-cis Retinol
4-Keto 9-cis Retinoic Acid,4-Oxo-9-cis-Retinoic Acid
13-cis-Retinoic Acid b-D-Glucopyranuronic Acid,13-cis-Retinoic Acid -D-Glucopyranuronic Acid
9-cis-Retinoic Acid -D-Glucopyranuronic Acid,9-cis-Retinoic Acid b-D-Glucopyranuronic Acid
9-CIS-RETINOIC ACID METHYL ESTER
4-KETO 13-CIS-RETINOIC ACID METHYL ESTER
13-CIS-RETINOIC ACID METHYL ESTER
9-CIS-RETINOIC ACID--N/H
9-CIS-TRETINOIN = 9-CIS-RETINOIC ACID
13-CIS-RETINOIC ACID--N/H