METHSUXIMIDE
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METHSUXIMIDE 속성
- 녹는점
- 52-53°
- 끓는 점
- bp0.1 121-122°
- 밀도
- 1.1255 (rough estimate)
- 굴절률
- 1.5440 (estimate)
- 저장 조건
- Refrigerator
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
- 수용성
- 2.8g/L(25℃)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
HS 번호 | 2925190100 | ||
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유해 물질 데이터 | 77-41-8(Hazardous Substances Data) | ||
독성 | LD50 orally in mice: 0.9 g/kg (Marshall, Vallance) |
METHSUXIMIDE C화학적 특성, 용도, 생산
개요
Methsuximide is a succinimide that is converted to N-desmethylmethosuximide, a channel blocker that targets low threshold calcium currents. Methsuximide is a substrate of cytochrome P450 (CYP) isoform 2C19 that, in turn, inhibits CYP2C19-mediated metabolism of biguanides. Methsuximide has been shown to have anticonvulsant properties in clinical trials.화학적 성질
Light Yellow Oil용도
A calcium channel succinimide antiepileptic drug. Anticonvulsant.Clinical Use
Although methsuximide is less commonly used, it may be indicated for the control of absence seizures refractory to other drugs. Although it does not precipitate tonic-clonic convulsions, it often is combined with phenytoin or phenobarbital when absence seizures coexist with tonic-clonic symptoms. Much of the efficacy of methsuximide is attributed to its desmethyl metabolite. The half-life of methsuximide is between 2.6 and 4.0 hours, but the half-life for N-desmethylsuximide is 25 hours, causing it to accumulate substantially. Concentrations of greater than 40 g/mL may be associated with toxicity. Methsuximide is considered to be more toxic than ethosuximide.METHSUXIMIDE 준비 용품 및 원자재
원자재
준비 용품
METHSUXIMIDE 공급 업체
글로벌( 74)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29898 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 25022 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15395 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 |
info@finetechnology-ind.com | China | 9624 | 58 |
changzhou huayang technology co., ltd | +8615250961469 |
2571773637@qq.com | China | 9827 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 |
sales@chemhifuture.com | China | 3136 | 58 |
Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 |
Ryan@jiutian-bio.com | China | 7431 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 |
3684455296@qq.com | China | 9311 | 58 |
METHSUXIMIDE 관련 검색:
Topiramate
ETHOSUXIMIDE
4-Phenyl-2-pyrrolidinone
3-PHENYLPYRROLIDINE
METHSUXIMIDE
PHENSUXIMIDE
N,N-DIMETHYL-2-PHENYLACETAMIDE
N-(2-PHENYL-PROPYL)-ACETAMIDE
ALPHA-METHYL-ALPHA-PHENYLSUCCINIMIDE
1,4-Dimethyl-2-pyrrolidone
4,4-dimethyl-2-pyrrolidinone
3-PHENYL-2-PYROLLIDINONE
NSC210729
N,N-DIMETHYLPIVALAMIDE
1,3-Dimethyl-2-pyrrolidone
Morsuximide
Benzenesulfonamide, 3-(2,5-dioxo-3-methyl-3-phenyl-1-pyrrolidinyl)-
Benzenesulfonamide, 4-(2,5-dioxo-3-(4-chlorophenyl)-3-methyl-1-pyrroli dinyl)-