무졸리미네

무졸리미네
무졸리미네 구조식 이미지
카스 번호:
55294-15-0
한글명:
무졸리미네
동의어(한글):
무졸리미네
상품명:
Muzolimine
동의어(영문):
Edrul;Muzolimine;BAY-g-2821;Muzolimina;Muzoliminum;5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one;3-Amino-1-(3,4-dichloro-α-methylbenzyl)-2-pyrazolin-5-one;3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1H-pyrazol-5(4H)-one;3H-Pyrazol-3-one, 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-
CBNumber:
CB2875411
분자식:
C11H11Cl2N3O
포뮬러 무게:
272.13
MOL 파일:
55294-15-0.mol

무졸리미네 속성

녹는점
127-129°
끓는 점
401.4±55.0 °C(Predicted)
밀도
1.5374 (rough estimate)
굴절률
1.5500 (estimate)
산도 계수 (pKa)
3.30±0.50(Predicted)
물리적 상태
Solid
색상
Light yellow to yellow

안전

독성 LD50 in mice, rats, dogs, rabbits (mg/kg): 1794, 1559, 2000, 1250 orally (Lorke, Mürmann)

무졸리미네 C화학적 특성, 용도, 생산

개요

Muzolimine is a structurally novel, pyrazolone diuretic with a high-ceiling profile. It is somewhat slower in onset than furosemide, but has a more prolonged effect, similar to the thiazides. Muzolimine has been shown to be effective in edema of cardiac, hepatic and renal origin. It also appears to be effective as an antihypertensive agent.

용도

Diuretic; antihypertensive.

World Health Organization (WHO)

Reports of neurological adverse effects, including paraesthesiae and paralyses, associated with prolonged use of high dosages of muzolimine, were received shortly after its introduction in 1984.

무졸리미네 준비 용품 및 원자재

원자재

준비 용품


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