Icaritin
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Icaritin 속성
- 녹는점
- 239℃
- 끓는 점
- 582.0±50.0 °C(Predicted)
- 밀도
- 1.359
- 인화점
- 206.7℃
- 저장 조건
- 2-8°C
- 용해도
- DMSO: 용해성5mg/mL, 투명(가온)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 6.44±0.40(Predicted)
- 색상
- 연한 노란색에서 진한 노란색까지
- 최대 파장(λmax)
- 368nm(MeOH)(lit.)
- InChI
- InChI=1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3
- InChIKey
- TUUXBSASAQJECY-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=C(OC)C=C2)OC2=C(C/C=C(/C)\C)C(O)=CC(O)=C2C(=O)C=1O
안전
WGK 독일 | 3 | ||
---|---|---|---|
RTECS 번호 | DJ3100870 | ||
HS 번호 | 29329990 |
Icaritin C화학적 특성, 용도, 생산
화학적 성질
Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from epimedium.용도
Icaritin is a hydrolytic product of Icariin, a traditional Chinese herbal medicine extracted from the Epimedium genus. Icaritin and Desmethylicaritin, is two metabolites of Icariin, dramatically inhibit the growth of most malignant cells. They also have significant antiangiogenesis properties, inhibiting or eliminating entirely the development of new malignant cells. Icaritin has been used in trials studying the treatment of Solid Tumors, Metastatic Breast Cancer, and Hepatocellular Carcinoma (HCC).Synthesis
The novel total synthesis of icaritin, naturally occurring with important bioactive 8-prenylflavonoid, was performed via a reaction sequence of 8 steps including Baker-Venkataraman reaction, chemoselective benzyl or methoxymethyl protection, dimethyldioxirane (DMDO) oxidation, O-prenylation, Claisen rearrangement and deprotection, starting from 2,4,6-trihydroxyacetophenone and 4-hydroxybenzoic acid in overall yields of 23%. The key step was Claisen rearrangement under microwave irradiation.Total Synthesis of Icaritin via Microwave-assistance Claisen Rearrangement
Mode of action
Icaritin is a flavonoid first isolated from the Chinese herb H. epimedii that demonstrates anticancer activity against a variety of tumor cell lines. Icaritin was shown in vitro to sustain extracellular signal–regulated kinase (ERK) activity through stimulating estrogen receptors. Prolonged ERK activation arrested the cell cycle in the G2 stage and subsequently triggered apoptosis. It has been shown to inhibit fatty acid synthase, reducing IGF-1-induced activation of STAT3 in several melanoma cell lines.Icaritin 준비 용품 및 원자재
원자재
준비 용품
Icaritin 공급 업체
글로벌( 228)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 |
gao490372054@gamil.com | China | 1250 | 58 |
PNP Biotech Co. Ltd | +8618516098983 |
sales@pnpbiotech.com | China | 1001 | 58 |
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 |
13119157289@163.com | China | 2972 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20294 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9332 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
Icaritin 관련 검색:
시코닌 페이민 아스트라갈린 파클리탁셀 노다케닌
Baohuoside V
(+/-)-Naringenin
Quercetin
Epimedium Extract
Icariin
epimedoside A
4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-8-(3-hydroxy-3-methylbutyl)-2-(4-methoxyphenyl)-
Genipin
Icariside I
13,14-Didehydromatridin-15-one
Catalpol
Cabazitaxel
Anhydroicaritin