VILAZODONE
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VILAZODONE 속성
- 녹는점
- 203-205°C
- 끓는 점
- 745.1±60.0 °C(Predicted)
- 밀도
- 1.34±0.1 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- 용해도
- DMSO(약간 용해됨)), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 15.98±0.30(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 연한 노란색~베이지색
- 안정성
- 흡습성이 매우 높음
- CAS 데이터베이스
- 163521-12-8
안전
유해 물질 데이터 | 163521-12-8(Hazardous Substances Data) |
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VILAZODONE C화학적 특성, 용도, 생산
개요
In January 2011, the U.S. FDA approved vilazodone for the treatment of major depressive disorder (MDD). Vilazodone is a novel antidepressant agent that combines potent serotonin reuptake inhibition (IC50=0.2 nM) with high affinity for 5-HT1A receptors (IC50=0.5 nM)and partial 5-HT1A receptor agonist functional activity. Vilazodone has good selectivity over other monoamine receptors and is efficacious in preclinical models of depression in rats and mice. Vilazodone is an indolylbutylpiperazine derivative that has been prepared by coupling of an indolylbutyl chloride or tosylate with 5-(piperazin-1-yl)benzofuran-2- carboxamide or the corresponding ester. The cyanoindole portion of vilazodone is important for conferring high affinity for both the serotonin transporter and the 5-HT1A receptor. Para-substitution on the phenyl group attached to the piperidine moiety reduces affinity for dopamine receptors, while the carboxamide group provides improved pharmacokinetic properties.화학적 성질
Light Yellow Solid용도
Labelled analogue of Vilazodone정의
ChEBI: A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder.VILAZODONE 준비 용품 및 원자재
원자재
준비 용품
VILAZODONE 공급 업체
글로벌( 239)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21670 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29897 | 58 |
Shochem(Shanghai) Co.,Ltd | 86-21-50800795 |
info@shochem.com | CHINA | 288 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 |
export01@shyrchem.com | CHINA | 1320 | 58 |
VILAZODONE 관련 검색:
1-BENZOFURAN-5-AMINE
Vilazodone Intermediate
Paliperidone
Linagliptin
Anidulafungin
Bexarotene
8-AZAGUANINE
Silodosin
Vilazodone impurity 1
1H-Indole-5-carbonitrile, 3-(4-hydroxybutyl)-
3-(4-Chloro-1-hydroxybutyl)-1H-indole-5-carbonitrile
ISO-PROPYLCHLOROBUTYRATE
5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-Benzofurancarboxylic acid
Vilazodone Hydrochloride
Vilazodone Impurity 24
Verazolonone related impurities
Vilazodone Impurity 5
Vilazodone Impurity 30