조카이논 C화학적 특성, 용도, 생산
Originator
Zocainone,ZYF Pharm Chemical
Manufacturing Process
21.0 g of N,N-diethylaminoethyl chloride are added drop by drop to 35.0 g of
the sodium salt of 3-o-hydroxyphenoxy-4-phenyl-3-butene-2-one suspended
in 600 ml of anhydrous acetone. The mixture is heated under reflux for 4 h,
the sodium chloride is filtered off, and the filtrate is evaporated to dryness.
The residue is dissolved in water and extracted a number of times with diethyl
ether. The ether phase, after drying over Na 2 SO 4 , is evaporated to dryness
and purified by distillation in a bulb apparatus, and 3-[o-(β-N,N-
diethylaminoethoxy)phenoxy]-4-phenyl-3-buten-2-one was obtained, boiling
point 200-210°C/0.6 mm Hg).
Therapeutic Function
Antiarrhythmic
조카이논 준비 용품 및 원자재
원자재
준비 용품
