Fumagillin
|
|
Fumagillin 속성
- 녹는점
- 194-195℃
- 알파
- D25 -26.6° (c = 1 in 95% ethanol)
- 끓는 점
- 484.03°C (rough estimate)
- 밀도
- 1.1368 (rough estimate)
- 굴절률
- 1.5800 (estimate)
- 인화점
- 2℃
- 저장 조건
- 2-8°C
- 용해도
- 에탄올: 1mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 4.27±0.10(Predicted)
- 색상
- 하얀색
- 감도
- Air Sensitive
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- InChIKey
- NGGMYCMLYOUNGM-ZILXAVPASA-N
- LogP
- 3.260 (est)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,F | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36-20/21/22-11 | ||
안전지침서 | 36-36/37-16-24/25 | ||
유엔번호(UN No.) | UN 1648 3 / PGII | ||
WGK 독일 | 3 | ||
RTECS 번호 | HE1750000 | ||
HS 번호 | 29419090 | ||
독성 | LD50 in mice (mg/kg): ~800 s.c. (DiPaolo) |
Fumagillin C화학적 특성, 용도, 생산
개요
Fumagillin is a fungal metabolite that has been found in A. fumigatus and has diverse biological activities. It inhibits methionyl aminopeptidase 2 (METAP2; IC50 = 10 nM). Fumagillin (10 ng/ml) inhibits tube formation in a rat blood vessel organ culture assay. It inhibits E. cuniculi replication in isolated rabbit kidney cells and canine embryo cells when used at a concentration of 5 μg/ml. In vivo, fumagillin (30 mg/kg per day) decreases tumor growth and the number of metastases in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. It also reduces subcutaneous and gonadal fat mass in a mouse model of high-fat diet-induced obesity. Formulations containing fumagillin have been used to treat conjunctival and intestinal microsporidial infections in immunocompromised patients.화학적 성질
White powder용도
Fumagillin is a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an an anti-inf ective and antiangiogenic agent.정의
An antibiotic substance produced by Aspergillus fumigatus.일반 설명
Fumagillin is an antibiotic obtained by the fermentation of certain strains of Aspergillus fumigatus with potent amoebicidal action.생물학적 활성
Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo . Also inhibits tumor growth in mice. Analog available, TNP 470 (N-(2-Chloroacetyl)carbamic acid (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl -2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester).Purification Methods
Forty grams of a commercial sample containing 42% fumagillin, 45% sucrose, 10% antifoam agent and 3% of other impurities are digested with 150mL of CHCl3. The insoluble sucrose is filtered off and washed with CHCl3. The combined CHCl3 extracts are evaporated almost to dryness at room temperature under reduced pressure. The residue is triturated with 20mL of MeOH, and the fumagillin is filtered off by suction. It is crystallised twice from 500mL of hot MeOH by standing overnight in a refrigerator (yellow needles). (The long-chain fatty ester used as antifoam agent is still present, but is then removed by repeated digestion, on a steam bath, with 100mL of diethyl ether.) For further purification, the fumagillin (10g) is dissolved in 150mL of 0.2M ammonia, and the insoluble residue is filtered off. The ammonia solution (cooled in running cold water) is then brought to pH 4 by careful addition of M HCl with constant shaking in the presence of 150mL of CHCl3. (Fumagillin is acid-labile and must be removed rapidly from the aqueous acid solution.) The CHCl3 extract is washed several times with distilled water, dried (Na2SO4) and evaporated under reduced pressure. The solid residue is washed with 20mL of MeOH. The fumagillin is filtered off by suction, then crystallised from 200mL of hot MeOH. [Tarbell et al. J Am Chem Soc 77 5610 1955.] Alternatively, 10g of fumagillin in 100mL CHCl3 is passed through a silica gel (5g) column to remove tarry material, and the CHCl3 is evaporated to leave an oil which gives fumagillin on crystallisation from amyl acetate. It recrystallises from MeOH (charcoal) or Me2CO/MeOH. The fumagillin is stored in dark bottles in the absence of oxygen and at low temperatures. [Schenk et al. J Am Chem Soc 77 5606 1955, Beilstein 19 III/IV 1012.]Fumagillin 준비 용품 및 원자재
원자재
준비 용품
Fumagillin 공급 업체
글로벌( 256)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 |
13119157289@163.com | China | 2969 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12459 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 |
daisy@crovellbio.com | China | 5838 | 58 |
Ouhuang Engineering Materials (Hubei) Co., Ltd | +86-86177 |
admin@hbouhuang.com | China | 2952 | 58 |
Apeloa production Co.,Limited | +8619933239880 |
admin@apcl.com.cn | China | 853 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21670 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29897 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8826 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Fumagillin 관련 검색:
3-아미노페놀
Aspergillus candidus Link
Aspergillus niger
Alternaria sp.
NETROPSIN
Vidarabine
Itraconazole
Voriconazole
Liraglutide
FASCAPLYSIN CHLORIDE
Penicillium expansum
Penicillium chrysogenum
FUMAGILLIN
AGM-1470
DECA-2,4,6,8(E,E,E,E)-TETRAENEDIOIC ACID
1,2,4,5-DIEPOXYPENTANE
FUMAGILLIN BICYCLOHEXYL AMMONIUM
fumagillin methyl ester