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Plazomicin

Plazomicin 구조식 이미지

카스 번호:: 1154757-24-0

상품명:: Plazomicin

동의어(영문):: ACHN 490;PlazoMicin;Plazomicin API;Sisomicin Impurity 10;IYDYFVUFSPQPPV-BPUQVFSTSA-N;Pirimicarb Impurity 9 (Ethirimol);O-2-AMino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)aMino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-4-C-Methyl-3-(MethylaMino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-4-aMino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptaMine;D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)amino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-

CBNumber:: CB32622979

분자식:: C25H48N6O10

포뮬러 무게:: 592.68282

MOL 파일:: 1154757-24-0.mol

속성

안전

용도

공급 업체 32

Plazomicin 속성

녹는점: >185°C (dec.)

끓는 점: 896.4±65.0 °C(Predicted)

밀도: 1.40±0.1 g/cm3(Predicted)

저장 조건: Hygroscopic, -20°C Freezer, Under inert atmosphere

용해도: 물(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 13.11±0.20(Predicted)

색상: 옅은 노랑

안전

Plazomicin C화학적 특성, 용도, 생산

개요

Plazomicin (PLZ) is a novel aminoglycoside approved by the U.S. Food and Drug Administration (FDA) for the treatment of complicated urinary tract infections (cUTI, including acute pyelonephritis) in adults due to multidrug-resistant carbapenem-resistant Enterobacterales (CRE) or extended-spectrum beta-lactamase (ESBL) producing bacteria. Despite the FDA Black Box Warning for aminoglycoside class effects, PLZ exhibited a favourable safety profile with decreased adverse effects in the largest in-human trials. In vitro, activity of PLZ, in comparison with that of other aminoglycosides, was found to be excellent, with 92.3% to 98.0% overall susceptibility in Enterobacterales, including CRE. Recently, PLZ was also shown to be active against certain multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative pathogens for which limited treatment options are left[1-2].

Plazomicin 준비 용품 및 원자재

원자재

준비 용품

Plazomicin 공급 업체

글로벌( 32)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3094	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21668	55
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3582	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10977	58
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Kaixin Chemical (Hong Kong) Limited	010-88886666-01 13112345678	loyson@tcypharm.com	China	595	55
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58