PCNA-I1
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PCNA-I1 속성
- 밀도
- 1.30±0.1 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
- 물리적 상태
- 결정성 고체
- 산도 계수 (pKa)
- 8.31±0.50(Predicted)
- 색상
- Light yellow to yellow
안전
PCNA-I1 C화학적 특성, 용도, 생산
개요
PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (Kd = 0.41 μM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells. It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC50s = 0.05-0.3 μM) over non-transformed cells (IC50s = 0.99-2 μM). PCNA-I1 leads to an accumulation of cells in the G1 phase during the first 24 hours of incubation and halts the cell cycle in the S and G2/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.PCNA-I1 준비 용품 및 원자재
원자재
준비 용품
PCNA-I1 공급 업체
글로벌( 44)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 |
757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 |
orders@jknbiochem.com | China | 4692 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 |
sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9707 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 |
klq@cw-bio.com | China | 3717 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 |
2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 |
sales@rechemscience.com | China | 2984 | 58 |