ChemicalBook >제품 카탈로그 >6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid 구조식 이미지

카스 번호:: 1467057-23-3

상품명:: 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

동의어(영문):: CS-2760;EOS-61684;PF 6409577;PF-06409577;PF 06409577;PF06409577;PF-06409577 >=98% (HPLC);PF-06409577;PF 06409577;PF06409577;6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid;1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-;Inhibitor,AMP-activated protein kinase,PF-06409577,AMPK,PF06409577,inhibit

CBNumber:: CB33142869

분자식:: C19H16ClNO3

포뮬러 무게:: 341.79

MOL 파일:: 1467057-23-3.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 66

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid 속성

끓는 점: 610.9±55.0 °C(Predicted)

밀도: 1.468±0.06 g/cm3(Predicted)

저장 조건: room temp

용해도: DMSO: 용해될 수 있다

산도 계수 (pKa): 3.60±0.30(Predicted)

물리적 상태: 가루

색상: 흰색에서 베이지색

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P305+P351+P338

눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

NFPA 704

	0
2		0

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid C화학적 특성, 용도, 생산

개요

PF-06409577 is an activator of AMP-activated protein kinase (AMPK) heterotrimers (K_d = 9 nM for α1β1γ1). In vitro, it selectively activates β1-containing AMPK isoforms (EC₅₀s = 2.18-7.03 nM) over β2-containing isoforms (EC₅₀s = ≥10 μM). PF-06409577 has an EC₅₀ value of 7 nM in an activation/protection TR-FRET assay using α1β1γ1 AMPK. In vivo, PF-06409577 (≥10 mg/kg) increases phosphorylation of AMPK in rat kidney. It decreases urinary albumin levels in a ZSF1 obese rat model of diabetes, metabolic syndrome, and renal disease when administered at a dose of 100 mg/kg.

용도

PF-06409577 has been used to determine its potential as a therapeutic agent for diabetic nephropathy.

일반 설명

PF-06409577 is a 6-chloro-indole derivative obtained from 5-bromo-6-chloro-indole.

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid 준비 용품 및 원자재

원자재

5-bromo-6-chloro-1H-Indole-3-carboxaldehyde methyl 5-bromo-6-chloro-1H-indole-3-carboxylate 1-(4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)cyclobutanol 1-(4-브로모페닐)사이클로부탄올 [4-(1-hydroxycyclobutyl)phenyl]boronic acid 1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutanol 5-브로모-6-클로로-인돌 1-Bromo-4-iodobenzene p-디브로모벤젠

준비 용품

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid 공급 업체

글로벌( 66)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10978	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Sichuan Biosynce Pharmatech Co., Ltd.	+8619950309693	diane@biosynce.com	China	4874	58

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid 관련 검색:

PF 03463275 PF-06446846 HYDROCHLORIDE PF-CBP-1.HCl PF 05105679 N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF 573228 PF-06882961 PF-04979064 PF-3758309 PF-05212384 PF-06281355 PF-562271 Ketohexokinase inhibitor 1 PF-6274484 PF-9366 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione