ChemicalBook >제품 카탈로그 >ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate 구조식 이미지

카스 번호:: 307519-88-6

상품명:: ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate

동의어(영문):: NMDI14;NMD Inhibitor;NMDI14 >=97% (HPLC);NMDI14, 10 mM in DMSO;inhibit,Inhibitor,NMDI14,NMDI-14,NMDI 14;ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate;3-Thiophenecarboxylic acid, 4,5-dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-, ethyl ester

CBNumber:: CB33589260

분자식:: C21H25N3O4S

포뮬러 무게:: 415.51

MOL 파일:: 307519-88-6.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 33

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate 속성

끓는 점: 658.8±55.0 °C(Predicted)

밀도: 1.250±0.06 g/cm3(Predicted)

저장 조건: 2-8°C

용해도: DMSO : ≥ 25 mg/mL (60.17 mM)

산도 계수 (pKa): 13.42±0.40(Predicted)

물리적 상태: 가루

색상: 흰색에서 베이지색

안전

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate C화학적 특성, 용도, 생산

용도

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:

to study its effects on differentiating cardiomyocytes
to study its effects on zebrafish pdzk1 gene-knockout embryos
to analyze its effects on the apoptosis of colorectal cancer cells

Biochem/physiol Actions

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate 준비 용품 및 원자재

원자재

준비 용품

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate 공급 업체

글로벌( 33)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32202	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38636	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
Zhengzhou HSH Science & Technology Co., Ltd.	0371-55932928 18937192232	1282296214@qq.com	China	495	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Guangzhou Zhiya Chemdrugs Co.,Ltd	18122150900	sculk28@163.com	China	646	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	9330	58
Twochem Co.Ltd.	021-58111628 15800915896	sales@twochem.com	China	1788	58